Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …

Originally considered an enigmatic protein, the sigma-1 receptor has recently been
identified as a unique ligand-regulated molecular chaperone in the endoplasmic reticulum …

Communication between the endoplasmic reticulum (ER) and mitochondrion is important for
bioenergetics and cellular survival. The ER supplies Ca 2+ directly to mitochondria via …

The membrane of the endoplasmic reticulum (ER) of a cell forms contacts directly with
mitochondria whereby the contact is referred to as the m itochondrion-a ssociated ER m …

Benzofuran core is a highly versatile, presents in many important natural products and
natural drugs. Many benzofuran containing synthetic drugs and clinical candidates have …

Sigma () receptors, initially described as a subtype of opioid receptors, are now considered
unique receptors. Pharmacological studies have distinguished two types of receptors …

Lösel, Ralf M., Elisabeth Falkenstein, Martin Feuring, Armin Schultz, Hanns-Christian
Tillmann, Karin Rossol-Haseroth, and Martin Wehling. Nongenomic Steroid Action …

Importance Agitation is common among patients with Alzheimer disease; safe, effective
treatments are lacking. Objective To assess the efficacy, safety, and tolerability of …

In order to characterize the localization of the sigma1 receptor in the adult rat central
nervous system, a polyclonal antibody was raised against a 20 amino acid peptide …

This review compares the biological and physiological function of Sigma receptors [σRs] and
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …