Intrinsically disordered regions (IDRs) are especially enriched among proteins that regulate
chromatin and transcription. As a result, mechanisms that influence specificity of IDR-driven …

The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

In the past decade important progress has been made in our understanding of the
epigenetic regulatory machinery. It has become clear that genetic aberrations in multiple …

Chromatin structure is a major barrier to gene transcription that must be disrupted and re-set
during each round of transcription. Central to this process is the Set2/SETD2 …

Histone modifying enzymes play critical roles in many key cellular processes and are
appealing proteins for targeting by small molecules in disease. However, while the functions …

Huntington's disease is a progressive neurodegenerative disease caused by expansion of
the polyglutamine domain in the first exon of huntingtin (HttEx1). The extent of expansion …

Self-binding peptides (SBPs) represent a novel biomolecular phenomenon spanning
between folding and binding, where a short peptide segment within a monomeric protein …

Protein misfolding and aggregation are a hallmark of several neurodegenerative diseases
(ND s). However, how protein aggregation leads to cytotoxicity and neurodegeneration is …

The methyltransferase SET domain–containing 2 (SETD2) was originally identified as
Huntingtin (HTT) yeast partner B. However, a SETD2 function associated with the HTT …

Despite the strong evidence linking the aggregation of the Huntingtin protein (Htt) to the
pathogenesis of Huntington's disease (HD), the mechanisms underlying Htt aggregation and …