The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolysis of cyclic AMP and
cyclic GMP, thereby regulating the intracellular concentrations of these cyclic nucleotides …

Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …

In the complex microcosm of a cell, information security and its faithful transmission are
critical for maintaining internal stability. To achieve a coordinated response of all its parts to …

Cardiac ryanodine receptor type 2 plays a key role in excitation–contraction coupling. The
ryanodine receptor type 2 channel protein is modulated by various post-translational …

Second messenger responses rely on where and when the enzymes that propagate these
signals become active. Spatial and temporal organization of certain signaling enzymes is …

By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine
monophosphate (cGMP), cyclic nucleotide phosphodiesterases are critical regulators of their …

Cyclic AMP (cAMP) plays a key regulatory role in most types of cells; however, the pathways
controlled by cAMP may present important differences between organisms and between …

The second messenger cyclic adenosine monophosphate (cAMP), which is produced by
adenylyl cyclases following stimulation of G-protein-coupled receptors, exerts its effect …

Using unbiased kinase profiling, we identified protein kinase A (PKA) as an active kinase in
small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by …