The aldol reaction is one of the most important carbon–carbon bond formations in synthetic
organic chemistry. An enantioselective aldol reaction should provide an enantioenriched …

Chiral primary α-amino amides, consisting of an adjacent enamine bonding site (Bronsted
base site), a hydrogen bonding site (Bronsted acid site), and flexible bulky substituent …

Herein, we have reported an environmentally friendly asymmetric aldol reaction between
isatins and ketones catalyzed by double-hydrogen-bonded primary amine organocatalysts …

Bcr-Abl is a key driver in the pathophysiology of CML. Broadening the chemical diversity of
Bcr-Abl kinase inhibitors to overcome drug resistance is a current medical demand for CML …

Despite the success of imatinib in CML therapy through Bcr-Abl inhibition, acquired drug
resistance occurs over time in patients. In particular, the resistance caused by T315I …

Enantioselective aldol reactions of various isatins with ketones using newly designed amino
amide organocatalysts were found to provide chiral 3‐substituted 3‐hydroxy‐2‐oxindoles in …

Amidation of amino acids using dichloro (methyl)(3, 3, 3-trifluoropropyl) silane (MTFPSCl 2)
and imidazole is described. MTFPSCl 2 activates the carboxy group and protects the α …

The synthesis and application of a newly designed C 2-symmetric chiral bifunctional
triamine family (C 2-CBT) is reported. These enantiopure chiral triamine scaffolds can be …

Sulphonamides derived from primary α‐amino acid were successfully applied to catalyze
the aldol reaction between isatin and cyclohexanone under neat conditions. More …

The contribution reports a novel type of chiral microspheres in which ferrocenyl amino-acid
derived catalytic moieties were integrated with optically active helical substituted …