Preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable and locally advanced pancreatic cancer

TF Stoop, RT Theijse, LWF Seelen… - Nature Reviews …, 2024 - nature.com
Surgical resection combined with systemic chemotherapy is the cornerstone of treatment for
patients with localized pancreatic cancer. Upfront surgery is considered suboptimal in cases …

Neoadjuvant treatment strategies in resectable pancreatic cancer

A Lambert, L Schwarz, M Ducreux, T Conroy - Cancers, 2021 - mdpi.com
Simple Summary Only 10–20% of patients with newly diagnosed resectable pancreatic
adenocarcinoma have potentially resectable disease. Upfront surgery is the gold standard …

“Conversion surgery” for locally advanced pancreatic cancer: A position paper by the study group at the joint meeting of the International Association of Pancreatology …

A Oba, M Del Chiaro, T Fujii, K Okano, TF Stoop… - Pancreatology, 2023 - Elsevier
Locally advanced pancreatic cancer (LAPC), which progresses locally and surrounds major
vessels, has historically been deemed unresectable. Surgery alone failed to provide curative …

Evaluating staging laparoscopy indications for pancreatic cancer based on resectability classification and treatment strategies for patients with positive peritoneal …

T Igarashi, M Fukasawa, T Watanabe… - Annals of …, 2024 - Wiley Online Library
Introduction The prognosis of pancreatic ductal adenocarcinoma (PDAC) in patients with
positive peritoneal washing cytology (CY1) is poor. We aimed to evaluate the results of …

Levels of tumor markers CEA/CA 19–9 in serum and peritoneal lavage predict postoperative recurrence in patients with pancreatic cancer

T Hata, K Chiba, M Mizuma, K Masuda… - Annals of …, 2022 - Wiley Online Library
Aim This study aimed to clarify the usefulness of tumor markers from peritoneal lavage in
selecting patients with a high risk of recurrence and predicting site‐specific recurrence in …

Circulating tumor DNA as a predictive marker for occult metastases in pancreatic cancer patients with radiographically non‐metastatic disease

T Hata, M Mizuma, M Iseki, T Takadate… - Journal of Hepato …, 2021 - Wiley Online Library
Purpose To elucidate the effectiveness of circulating tumor DNA (ctDNA) for predicting occult
metastases in patients with pancreatic cancer without apparent metastases. Methods …

Synopsis of a clinical practice guideline for pancreatic ductal adenocarcinoma with peritoneal dissemination in Japan; Japan Peritoneal Malignancy Study Group

S Satoi, N Takahara, T Fujii, H Isayama… - Journal of Hepato …, 2022 - Wiley Online Library
Patients with pancreatic ductal adenocarcinoma (PDAC) with peritoneal dissemination have
a dismal prognosis because discontinuation of systemic chemotherapy is required for …

A simple risk score for detecting radiological occult metastasis in patients with resectable or borderline resectable pancreatic ductal adenocarcinoma

T Sakaguchi, S Satoi, D Hashimoto… - Journal of Hepato …, 2022 - Wiley Online Library
Background We advocated carbohydrate antigen (CA) 19‐9≥ 150 U/mL and tumor size≥
30 mm as “high‐risk markers” for predicting unresectability among patients with …

Outcomes and risks in palliative pancreatic surgery: an analysis of the German StuDoQ| Pancreas registry

FO Hofmann, RC Miksch, M Weniger, T Keck… - BMC surgery, 2022 - Springer
Background Non-resectability is common in patients with pancreatic ductal adenocarcinoma
(PDAC) due to local invasion or distant metastases. Then, biliary or gastroenteric bypasses …

MicroRNA-593-3p expression in peritoneal lavage fluid as a prognostic marker for pancreatic cancer patients undergoing staging laparoscopy

T Hata, M Mizuma, K Masuda, K Chiba, M Ishida… - Annals of Surgical …, 2021 - Springer
Background Some presumed resectable pancreatic cancer patients harbor radiographically
occult metastases that are incidentally identified at the time of abdominal exploration. This …