Breast cancer is a heterogeneous disease, divisible into a variable number of clinical
subtypes. A fundamental question is how many etiological classes underlie the clinical …

Genetic and lifestyle/environmental factors are implicated in the aetiology of breast cancer.
This review summarizes the current state of knowledge on rare high penetrance mutations …

Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …

Purpose Mutations in the BRCA1 and BRCA2 genes confer greater risk of developing breast
cancer. We determined whether tumor pathologic features and clinical features differ in …

Background Many cases of hereditary breast cancer are due to mutations in either the
BRCA1 or the BRCA2 gene. The histopathological changes in these cancers are often …

Background. Researchers question whether estrogen receptorα-negative (ERN) and-
positive (ERP) represent different stages of one disease or different breast cancer types …

ContextAmong cancer-free women aged 35 years or older, tamoxifen reduced the incidence
of estrogen receptor (ER)–positive but not ER-negative breast cancer. The effect of …

Background The presence of deleterious mutations in breast cancer 1 gene (BRCA1) or
breast cancer 2 gene (BRCA2) significantly increases the risk of developing some cancers …

Abstract The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2, are the dynamic
regulators of genomic integrity. Inherited mutations in these genes are associated with the …

Background: Previous studies have reported a breast cancer (BC) risk reduction of
approximately 50% after risk-reducing salpingo-oophorectomy (RRSO) in BRCA1/2 …