Inhibitor of DNA binding (ID) proteins are transcriptional regulators that control the timing of
cell fate determination and differentiation in stem and progenitor cells during normal …

Id proteins are important parts of signaling pathways involved in development, cell cycle and
tumorigenesis. They were first shown to act as dominant negative antagonists of the basic …

Ewing's family tumors (EFTs) are highly malignant tumors arising from bone and soft tissues
that exhibit EWS–FLI1 or variant EWS–ETS gene fusions in more than 85% of the cases …

Over the past few decades, biologists have identified key molecular signatures associated
with a wide range of human cancers. Recently, animal models have been particularly useful …

Translocated in liposarcoma, Ewing's sarcoma and TATA-binding protein-associated factor
15 constitute an interesting and important family of proteins known as the TET proteins. The …

Inhibitors of DNA binding (IDs) antagonize basic-helix-loop-helix (bHLH) transcription
factors to inhibit differentiation and maintain stem cell fate. ID ubiquitination and proteasomal …

Sarcomas account for less than 10% of all human malignancies that are believed to
originate from as yet poorly defined mesenchymal progenitor cells. They constitute some of …

Since the gene encoding Id1 was cloned in 1990, Id proteins have been implicated in
regulating a variety of cellular processes, including cellular growth, senescence …

Abstract Helix-loop-helix (HLH) proteins are transcriptional regulators that control a wide
variety of developmental pathways in both invertebrate and vertebrate organisms. Results …

Background Chromosomal translocations generating oncogenic transcription factors are the
hallmark of a variety of tumors, including many sarcomas. Ewing sarcoma family of tumors …