Triple-negative breast cancer (TNBC) is the most complex, aggressive and fatal subtype of
breast cancer. Owing to the lack of targeted therapy and heterogenic nature of TNBC …

Since their isolation in the early 1990s, members of the Hedgehog family of intercellular
signaling proteins have come to be recognized as key mediators of many fundamental …

Signalling by Wnt proteins is finely balanced to ensure normal development and tissue
homeostasis while avoiding diseases such as cancer. This is achieved in part by Notum, a …

Hedgehog proteins constitute one of a small number of families of secreted signals that have
a central role in the development of metazoans. Genetic analyses in flies, fish and mice have …

The steroidal alkaloid cyclopamine has both teratogenic and antitumor activities arising from
its ability to specifically block cellular responses to vertebrate Hedgehog signaling. We show …

CREB binding protein (CBP) and p300 were both identified initially in protein interaction
assays–the former through its association with the transcription factor CREB (Chrivia et al …

Expression of the Drosophila segment polarity genes is initiated by a pre-pattern of pair-rule
gene products and maintained by a network of regulatory interactions throughout several …

During hedgehog biosynthesis, autocatalytic processing produces a lipid-modified amino-
terminal fragment (residues 24–197 in the human Sonic hedgehog sequence) that is …

All insects possess homologous segments, but segment specification differs radically among
insect orders. In Drosophila, maternal morphogens control the patterned activation of gap …

In vertebrates, Hedgehog (Hh) signaling initiated in primary cilia activates the membrane
protein Smoothened (Smo) and leads to activation of Gli proteins, the transcriptional …