Classically, superoxide anion O2•− and reactive oxygen species ROS play a dual role. At
the physiological balance level, they are a by-product of O2 reduction, necessary for cell …

Free radicals are chemical species (atoms, molecules, or ions) containing one or more
unpaired electrons in their external orbitals and generally display a remarkable reactivity …

There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …

Chronic inflammatory diseases are associated with accelerated atherosclerosis and
increased risk of cardiovascular diseases (CVD). As the pathogenesis of atherosclerosis is …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Free radical production occurs continuously in all cells as part of normal cellular function.
However, excess free radical production originating from endogenous or exogenous …

Reactive oxygen species (ROS) and other radicals are involved in a variety of biological
phenomena, such as mutation, carcinogenesis, degenerative and other diseases …

Oxidative stress is an increase in the reduction potential or a large decrease in the reducing
capacity of the cellular redox couples. A particularly destructive aspect of oxidative stress is …

Background—Increased superoxide production contributes to reduced vascular nitric oxide
(NO) bioactivity and endothelial dysfunction in experimental models of diabetes. We …

Impairment of normal spermatogenesis and sperm function are the most common causes of
male factor infertility. Abnormal sperm function is difficult to evaluate and treat. There is a …