Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …

Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
healthy and diseased brain. As a result, there is a large body of evidence that associates …

Background Increasingly, evidence from brain imaging supports the role of
neuroinflammation in dementia progression. Yet, it is not clear if there are patterns of spatial …

Increasing evidence indicates a possible causal link between neuroinflammation and
neurological disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) …

Alzheimer's disease, the commonest cause of dementia, is a growing global health concern
with huge implications for individuals and society. In this review, current understanding of …

Alzheimer's disease (AD) is a devastating and progressive neurodegenerative disease for
which there is no cure. Mild cognitive impairment (MCI) is considered a prodromal stage of …

Background Cognitive decline occurs frequently in Parkinson's disease (PD), which greatly
decreases the quality of life of patients. However, the mechanisms remain to be investigated …

Tau pathology, neuroinflammation, and neurodegeneration are key aspects of Alzheimer's
disease. Understanding whether these features predict cognitive decline, alone or in …

Introduction The 18-kDa translocator protein (TSPO) is increasingly recognized as a
molecular target for PET imaging of inflammatory responses in various central nervous …

In vivo exploration of activated microglia in neurodegenerative diseases is achievable by
Positron Emission Tomography (PET) imaging, using dedicated radiopharmaceuticals …