Neural plasticity, a fundamental mechanism of neuronal adaptation, is disrupted in
depression. The changes in neural plasticity induced by stress and other negative stimuli …

Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

Key points Chronic (psychosocial) stress changes gut microbiota composition, as well as
inducing behavioural and physiological deficits. The microbial metabolites short‐chain fatty …

The neurobiology of stress and the neurobiology of social behavior are deeply intertwined.
The social environment interacts with stress on almost every front: social interactions can be …

Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …

Ammonia has been long recognized as a metabolic waste product with well-known
neurotoxic effects. However, little is known about the beneficial function of endogenous …

Chronic stress-induced emotional disorders like anxiety and depression involve imbalances
between the excitatory glutamatergic system and the inhibitory GABAergic system in the …

Altered myelin structure and oligodendrocyte function have been shown to correlate with
cognitive and motor dysfunction and deficits in social behavior. We and others have …

Major depression is a prevalent emotion disorder. Chronic stressful life in genetically
susceptible individuals is presumably a major etiology that leads to neuron and synapse …

Chronic stress induces adaptive changes in the brain via the cumulative action of
glucocorticoids, which is associated with mood disorders. Here we show that repeated daily …