Hyaluronan is an extracellular and cell-surface-associated polysaccharide that is
traditionally regarded as a biological'goo'that participates in lubricating joints or holding …

Nearly 100 proteins are known to be regulated by hsp90. Most of these substrates or “client
proteins” are involved in signal transduction, and they are brought into complex with hsp90 …

Hyperthermia has long been used for cancer treatment, either alone or in combination with
chemotherapy, radiation therapy, or both. Its efficacy and versatility continue to be well …

Cartilage and bone are severely affected by glucocorticoids (GCs), steroid hormones that
are frequently used to treat inflammatory diseases. Major complications associated with long …

We used a cellular system to elucidate the molecular determinants of the large immunophilin
FK506-binding proteins (FKBP) 51 and-52 for their action on the glucocorticoid receptor in …

Hyaluronan has been implicated in biological processes such as cell adhesion, migration
and proliferation. Traditionally, it was thought to be associated with the extracellular matrix …

Hsp90 is required for the normal activity of steroid receptors, and in steroid receptor
complexes it is typically bound to one of the immunophilin‐related co‐chaperones: the …

The glucocorticoid receptor (GR) belongs to the superfamily of steroid receptors and is an
important regulator of physiological and metabolic processes. In its inactive state, GR is …

The IKK complex, containing two catalytic subunits IKKα and IKKβ and a regulatory subunit
NEMO, plays central roles in signal-dependent activation of NF-κB. We identify Cdc37 and …

Hsp90 chaperones receive much attention due to their role in cancer and other pathological
conditions, and a tremendous effort of many laboratories has contributed in the past …