Immunodeficiency-associated lymphoproliferative disorders (IA-LPDs) are pathologically
and clinically heterogeneous. In many instances, similar features are shared by a spectrum …

Tumor necrosis factor-alpha (TNF-α) is a well-known pro-inflammatory cytokine responsible
for the modulation of the immune system. TNF-α plays a critical role in almost every type of …

Children and adolescents with Crohn's disease (CD) present often with a more complicated
disease course compared to adult patients. In addition, the potential impact of CD on growth …

Context Concerns exist regarding the potential development of malignancies in patients with
rheumatoid arthritis (RA) who are receiving biologic response modifiers (BRMs). Objective …

OBJECTIVES: The risk of non-Hodgkin's lymphoma (NHL) with tumor necrosis factor alpha
(TNF-α) inhibitors is unclear, whether related to concomitant thiopurines usage or due to the …

Background Infliximab (IFX) combined with azathioprine (AZA) is more effective than IFX
monotherapy in inflammatory bowel disease (IBD). Aim To identify the AZA optimal dose that …

Importance Therapy-related myeloid neoplasms are a potentially life-threatening
consequence of treatment for autoimmune disease (AID) and an emerging clinical …

Background Lymphomas comprise a heterogeneous group of malignant diseases with
highly variable prognosis. Rheumatoid arthritis (RA) is associated with a twofold increased …

Aim There is a requirement of an expansive and up to date review of surgical management
of inflammatory bowel disease (IBD) that can dovetail with the medical guidelines produced …

Hepatosplenic T-cell lymphoma (HSTCL) is a rare subtype of T-cell lymphoma associated
with an aggressive clinical course and a worse prognosis. HSTCL develops in the setting of …