Extensive burn wounds are difficult to manage and repair. Several engineered skin
substitutes have been developed to aid in this process. These substitutes are designed with …

Skin indicates a person's state of health and is so important that it influences a person's
emotional and psychological behavior. In this context, the effective treatment of wounds is a …

Background: Yannas and Burke developed the concept of the dermal regeneration template
in the 1970s. It is now a widely accepted tool in the treatment of burns as well as in …

Abstract Background INTEGRA® Dermal Regeneration Template is a well-known and
widely used acellular dermal matrix. Although it helps to solve many challenging problems …

Background: Standard care for lower extremity injuries with exposed bone or tendon is
vascularized tissue transfer. In patients with deep and extensive burn injuries, these options …

Background Artificial dermal templates play an important role in physiologic wound closure
after injury. In addition to contributing to stable, durable and flexible wound closure, they …

The bilayered dermal substitute Integra (Integra Life Sciences Corp., Plainsboro, NJ) was
developed and has been widely used as primary coverage for excised acute burns. Our take …

Background: Advances in critical care allowed survival of large total body surface burn
patients in the 1970s, spawning the development of artificial skin for burn victims. Lack of …

Summary Background Dermal regenerative matrices (DRMs) have been used for several
decades in the treatment of acute and reconstructive burn injury. The objective of this study …

Advances in cellular biology and knowledge in wound healing and growth factors have
given us a wide variety of choices to attack the problem of the complex burn wound. Split …