Pathophysiology of radiation-induced dysphagia in head and neck cancer
Oncologic treatments, such as curative radiotherapy and chemoradiation, for head and neck
cancer can cause long-term swallowing impairments (dysphagia) that negatively impact …
cancer can cause long-term swallowing impairments (dysphagia) that negatively impact …
The emerging role of skeletal muscle oxidative metabolism as a biological target and cellular regulator of cancer-induced muscle wasting
While skeletal muscle mass is an established primary outcome related to understanding
cancer cachexia mechanisms, considerable gaps exist in our understanding of muscle …
cancer cachexia mechanisms, considerable gaps exist in our understanding of muscle …
[HTML][HTML] Sex differences in the relationship of IL-6 signaling to cancer cachexia progression
A devastating aspect of cancer cachexia is severe loss of muscle and fat mass. Though
cachexia occurs in both sexes, it is not well-defined in the female. The Apc Min/+ mouse is …
cachexia occurs in both sexes, it is not well-defined in the female. The Apc Min/+ mouse is …
Eccentric contraction-induced myofiber growth in tumor-bearing mice
Cancer cachexia is characterized by the progressive loss of skeletal muscle mass. While
mouse skeletal muscle's response to an acute bout of stimulated low-frequency concentric …
mouse skeletal muscle's response to an acute bout of stimulated low-frequency concentric …
Radiation induces long‐term muscle fibrosis and promotes a fibrotic phenotype in fibro‐adipogenic progenitors
N Collao, D D'Souza, L Messeiller… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Radiation‐induced muscle pathology, characterized by muscle atrophy and
fibrotic tissue accumulation, is the most common debilitating late effect of therapeutic …
fibrotic tissue accumulation, is the most common debilitating late effect of therapeutic …
Muscle wasting in cancer: opportunities and challenges for exercise in clinical cancer trials
Background Low muscle in cancer is associated with an increase in treatment‐related
toxicities and is a predictor of cancer‐related and all‐cause mortality. The mechanisms of …
toxicities and is a predictor of cancer‐related and all‐cause mortality. The mechanisms of …
In situ macrophage phenotypic transition is affected by altered cellular composition prior to acute sterile muscle injury
Key points The in situ phenotypic switch of macrophages is delayed in acute injury following
irradiation. The combination of bone marrow transplantation and local muscle radiation …
irradiation. The combination of bone marrow transplantation and local muscle radiation …
Inflammatory signalling regulates eccentric contraction‐induced protein synthesis in cachectic skeletal muscle
Background Skeletal muscle responds to eccentric contractions (ECC) with an anabolic
response that involves the induction of protein synthesis through the mechanistic target of …
response that involves the induction of protein synthesis through the mechanistic target of …
Lewis lung carcinoma regulation of mechanical stretch-induced protein synthesis in cultured myotubes
S Gao, JA Carson - American journal of physiology-Cell …, 2016 - journals.physiology.org
Mechanical stretch can activate muscle and myotube protein synthesis through mammalian
target of rapamycin complex 1 (mTORC1) signaling. While it has been established that …
target of rapamycin complex 1 (mTORC1) signaling. While it has been established that …
The Effect of Estradiol Administration on Muscle Mass Loss and Cachexia Progression in Female ApcMin/+ Mice
BR Counts, DK Fix, KL Hetzler… - Frontiers in Endocrinology, 2019 - frontiersin.org
Cancer cachexia is a multifactorial muscle wasting condition characterized by severe body
weight and muscle mass loss which is secondary to chronic disease. The mechanistic …
weight and muscle mass loss which is secondary to chronic disease. The mechanistic …