Covalent drugs have been used to treat diseases for more than a century, but tools that
facilitate the rational design of covalent drugs have emerged more recently. The purposeful …

Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is
emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation …

The growing field of immunometabolism has taught us how metabolic cellular reactions and
processes not only provide a means to generate ATP and biosynthetic precursors, but are …

Electrophilic compounds originating from nature or chemical synthesis have profound effects
on immune cells. These compounds are thought to act by cysteine modification to alter the …

Nuclear factor erythroid 2‐related factor 2 (NRF2) is a master transcriptional regulator of
genes whose products defend our cells for toxic and oxidative insults. Although NRF2 …

Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet …

Psoriasis is a multifactorial recalcitrant inflammatory skin disease characterized by
bothersome scaly reddish plaques especially on frequently chafed body parts, such as the …

Chemoproteomics has made significant progress in investigating small-molecule-protein
interactions. However, the proteome-wide profiling of cysteine ligandability remains …

Dimethyl fumarate (DMF) is an antioxidative and anti-inflammatory drug approved for
treatment of multiple sclerosis and psoriasis; however, beneficial effects of DMF have also …

Despite the emerging importance of reactive electrophilic drugs, deconvolution of their
principal targets remains difficult. The lack of genetic tractability/interventions and reliance …