The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

At any point 1–5 days following ascent to altitudes≥ 2500 m, individuals are at risk of
developing one of three forms of acute altitude illness: acute mountain sickness, a syndrome …

Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more
than 100 million lowlanders visit mountainous areas above 2500 m annually. The …

The delivery of many potentially therapeutic and diagnostic compounds to specific areas of
the brain is restricted by brain barriers, of which the most well known are the blood–brain …

Take home figure Adapted from Bärtsch and Gibbs Physiological response to hypoxia. Life-
sustaining oxygen delivery, in spite of a reduction in the partial pressure of inhaled oxygen …

Cognitive function defines performance in objective tasks that require conscious mental
effort. Extreme environments, namely heat, hypoxia, and cold can all alter human cognitive …

Background The concentration of oxygen in air remains constant at 21% regardless of the
altitude. However, the partial pressure of oxygen decreases with increasing altitude …

High-altitude cerebral edema (HACE) and acute mountain sickness (AMS) are
neuropathologies associated with rapid exposure to hypoxia. However, speculation remains …

Both genomics-and proteomics-based investigations have identified several essential
genes, proteins, and pathways that may facilitate human adaptive genotype/phenotype in a …

Transcranial Doppler is a widely used noninvasive technique for assessing cerebral artery
blood flow. All previous high altitude studies assessing cerebral blood flow (CBF) in the field …