The silicon carbide fiber-reinforced silicon carbide matrix (SiC/SiC) composite system for
fusion applications has seen a continual evolution from development a fundamental …

Targeted covalent inhibitors have regained widespread attention in drug discovery and have
emerged as powerful tools for basic biomedical research. Fueled by considerable …

Background The use of abacavir a potent HIV—1 nucleosideanalogue reverse—
transcriptase inhibitor is complicated by a potentially life-threatening hypersensitivity …

Idiosyncratic adverse drug reactions are unpredictable, dose-independent and potentially
life threatening; this makes them a major factor contributing to the cost and uncertainty of …

Liver plays a central role in the metabolism and excretion of xenobiotics which makes it
highly susceptible to their adverse and toxic effects. Liver injury caused by various toxic …

Immune-mediated (IM) adverse drug reactions (ADRs) are an underrecognized source of
preventable morbidity, mortality, and cost. Increasingly, genetic variation in the HLA loci is …

The occurrence of idiosyncratic adverse drug reactions during late clinical trials or after a
drug has been released can lead to a severe restriction in its use and even in its withdrawal …

Susceptibility to a clinically significant drug hypersensitivity syndrome associated with
abacavir use seems to have a strong genetic component. We have previously shown that …

Microbial pathogens including Enterobacteriaceae family members bear different antibiotic
resistance genes comprising Extended-Spectrum-ß-Lactamases (ESBLs) and Metallo-ß …

The conventional pipeline for biomarker development involves a discovery phase, typically
conducted by mass spectrometry (MS), followed by validation and clinical application …