Activators and target genes of Rel/NF-κB transcription factors

HL Pahl - Oncogene, 1999 - nature.com
The vertebrate transcription factor NF-κB is induced by over 150 different stimuli. Active NF-
κB, in turn, participates in the control of transcription of over 150 target genes. Because a …

Regulation of interleukin-8 gene expression

KA Roebuck - Journal of interferon & cytokine research, 1999 - liebertpub.com
Interleukin-8 (IL-8), a member of the CXC chemokine family, is an important activator and
chemoattractant for neutrophils and has been implicated in a variety of inflammatory …

[HTML][HTML] Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19

Y Zaid, E Dore, I Dubuc, AS Archambault… - Journal of Allergy and …, 2021 - Elsevier
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can
lead to a variety of clinical outcomes, ranging from the absence of symptoms to severe acute …

Vitamin D decreases respiratory syncytial virus induction of NF-κB–linked chemokines and cytokines in airway epithelium while maintaining the antiviral state

S Hansdottir, MM Monick, N Lovan… - The journal of …, 2010 - journals.aai.org
Epidemiological studies suggest that low vitamin D levels may increase the risk or severity of
respiratory viral infections. In this study, we examined the effect of vitamin D on respiratory …

Rhinoviruses infect the lower airways

NG Papadopoulos, PJ Bates, PG Bardin… - Journal of Infectious …, 2000 - academic.oup.com
Rhinoviruses are the major cause of the common cold and a trigger of acute asthma
exacerbations. Whether these exacerbations result from direct infection of the lower airway …

ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation

I Boldogh, A Bacsi, BK Choudhury… - The Journal of …, 2005 - Am Soc Clin Investig
Pollen exposure induces allergic airway inflammation in sensitized subjects. The role of
antigenic pollen proteins in the induction of allergic airway inflammation is well …

The role of nuclear factor-κ B in pulmonary diseases

JW Christman, RT Sadikot, TS Blackwell - Chest, 2000 - Elsevier
Nuclear factor-κ B (NF-κB) is a family of DNA-binding protein factors that are required for
transcription of most proinflammatory molecules, including adhesion molecules, enzymes …

Retinoic acid-inducible gene I mediates early antiviral response and Toll-like receptor 3 expression in respiratory syncytial virus-infected airway epithelial cells

P Liu, M Jamaluddin, K Li, RP Garofalo… - Journal of …, 2007 - Am Soc Microbiol
Respiratory syncytial virus (RSV) is one of the most common viral pathogens causing severe
lower respiratory tract infections in infants and young children. Infected host cells detect and …

Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression

BD Rudd, E Burstein, CS Duckett, X Li… - Journal of …, 2005 - Am Soc Microbiol
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection in
young infants worldwide. Previous studies have reported that the induction of interleukin …

Respiratory syncytial virus: the virus, the disease and the immune response

PL Ogra - Paediatric respiratory reviews, 2004 - Elsevier
RSV is the primary cause of hospitalisation in the first year of life for children in most parts of
the world, and nearly 100% of children in the USA are infected with the virus by 2 to 3 years …