Liquid biopsies are increasingly used for cancer molecular profiling that enables a precision
oncology approach. Circulating extracellular nucleic acids (cell-free DNA; cfDNA) …

Over the past decade, various liquid biopsy techniques have emerged as viable alternatives
to the analysis of traditional tissue biopsy samples. Such surrogate 'biopsies' offer numerous …

Diagnosing, selecting therapy for, and monitoring cancer in patients using a minimally
invasive blood test represents a significant advance in precision medicine. Wide variability …

Purpose To explore whether targeted next generation sequencing (NGS) of liquid biopsy in
advanced non-small cell lung cancer (NSCLC) could potentially overcome the innate …

Background The standard neoadjuvant treatments in patients with esophageal squamous
cell carcinoma (ESCC) still have either poor safety or efficacy. Better therapies are needed …

Liquid biopsies using cell-free circulating tumor DNA (ctDNA) are being used frequently in
both research and clinical settings. ctDNA can be used to identify actionable mutations to …

Intrahepatic cholangiocarcinoma (ICC) is a relatively rare but highly aggressive tumor type
that responds poorly to chemotherapy and immunotherapy. Comprehensive molecular …

Cell-free DNA (cfDNA) has pioneered the development of noninvasive prenatal testing and
liquid biopsy, its emerging applications include organ transplantation, autoimmune …

EGFR exon 20 insertions (EGFR e20ins) account for up to 10% of EGFR mutations in lung
cancer; however, tumors with EGFR e20ins had poor response rates to EGFR tyrosine …

Background Microsatellite instability in colon cancer implies favorable therapeutic outcomes
after checkpoint blockade immunotherapy. However, the molecular nature of microsatellite …