Abstract Type 1 diabetes (T1D) results from an autoimmune destruction of insulin-producing
beta cells that requires lifelong insulin treatment. While significant advances have been …

Calpain activity has been implicated in several cellular processes such as cell signaling,
apoptosis, exocytosis, mitochondrial metabolism and cytoskeletal remodeling. Evidence has …

An increase in the prevalence of type 2 diabetes has been consistently observed among
residents of high arsenic exposure areas. We have previously shown that in rat pancreatic β …

Cardiovascular disease is the leading cause of morbidity and mortality in the industrialized
world. Familial aggregation of cardiovascular risk factors is a frequent finding, but genetic …

Whereas most calpains are cytosolic proteases, calpain 10 is resident in mitochondria and is
important in mitochondrial homeostasis. Because calpain 10 has been implicated in type 2 …

Chronic arsenic exposure results in higher risk of skin, lung, and bladder cancer, as well as
cardiovascular disease and diabetes. The purpose of this study was to investigate the effects …

Exposure to arsenic is associated with increased risk of developing insulin resistance and
type 2 diabetes. The proteases calpain-1 (CAPN1), calpain-2 (CAPN2) and calpain-10 …

Abstract Calpain-10 (CAPN10) belongs to the calpain superfamily. Genetic polymorphisms
of the CAPN10 gene are associated with susceptibility to develop type 2 diabetes mellitus …

Diabetes mellitus (DM) is an enormous public health issue worldwide. Recent data suggest
that chronic arsenic exposure is linked to the risk of developing type 1 and type 2 DM, albeit …

Calpains, Ca2+-activated cysteine proteases, have been implicated in the progression of
multiple disease states. We recently identified calpain 10 as a mitochondrial calpain that is …