Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
C Gao, J Jiang, Y Tan, S Chen - Signal transduction and targeted …, 2023 - nature.com
Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …
single-cell technologies have revealed that these reactive microglia were with high spatial …
Advancing cell therapy for neurodegenerative diseases
S Temple - Cell stem cell, 2023 - cell.com
Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …
[HTML][HTML] A cellular taxonomy of the adult human spinal cord
The mammalian spinal cord functions as a community of cell types for sensory processing,
autonomic control, and movement. While animal models have advanced our understanding …
autonomic control, and movement. While animal models have advanced our understanding …
Nuclear pore complexes—a doorway to neural injury in neurodegeneration
AN Coyne, JD Rothstein - Nature Reviews Neurology, 2022 - nature.com
The genetic underpinnings and end-stage pathological hallmarks of neurodegenerative
diseases are increasingly well defined, but the cellular pathophysiology of disease initiation …
diseases are increasingly well defined, but the cellular pathophysiology of disease initiation …
Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation
A repeat expansion in the C9orf72 (C9) gene is the most common genetic cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we investigate …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we investigate …
C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive motor neuron loss, with additional pathophysiological involvement of non …
progressive motor neuron loss, with additional pathophysiological involvement of non …
[HTML][HTML] Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation
Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …
Mechanisms of ferroptosis and emerging links to the pathology of neurodegenerative diseases
Neurodegenerative diseases are a diverse class of diseases attributed to chronic
progressive neuronal degeneration and synaptic loss in the brain and/or spinal cord …
progressive neuronal degeneration and synaptic loss in the brain and/or spinal cord …
Comprehensive research on past and future therapeutic strategies devoted to treatment of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a rapidly debilitating fatal neurodegenerative disorder,
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …
Exploring microglia and their phenomenal concatenation of stress responses in neurodegenerative disorders
Neuronal cells are highly functioning but also extremely stress-sensitive cells. By defending
the neuronal cells against pathogenic insults, microglial cells, a unique cell type, act as the …
the neuronal cells against pathogenic insults, microglial cells, a unique cell type, act as the …