Immunoactinopathies caused by mutations in actin‐related proteins are a growing group of
inborn errors of immunity (IEI). Immunoactinopathies are caused by a dysregulated actin …

Invadopodia are actin-rich protrusions developed by transformed cells in 2D/3D
environments that are implicated in extracellular matrix (ECM) remodeling and degradation …

Cardiovascular disease is an important cause of death in patients with chronic kidney
disease (CKD). Protein-bound uremic toxins, such as p-cresyl and indoxyl sulfate (IS), are …

Podosomes are dynamic cell adhesions that are also sites of extracellular matrix
degradation, through recruitment of matrix-lytic enzymes, particularly of matrix …

The development of epithelial-to-mesenchymal transition (EMT) like features is emerging as
a critical factor involved in the pathogenesis of acute myeloid leukaemia (AML). However …

Invadosomes are actin rich protrusive structures that facilitate invasive migration in multiple
cell types. Comprised of invadopodia and podosomes, these highly dynamic structures …

Integrin-linked kinase (ILK) has been implicated as a molecular driver and mediator in both
inflammation and tumorigenesis of the colon. However, a role for ILK in the tumor …

Local membrane phospholipid enrichment serves as docking platform for signaling proteins
involved in many processes including cell adhesion and migration. Tissue-resident dendritic …

Inorganic nanoparticles have emerged as an attractive theranostic tool applied to different
pathologies such as cancer. However, the increment in inorganic nanoparticle application in …

Our previous study reported that muscle cell enhancement factor 2C (MEF2C) was fully
activated after inhibition of the phosphorylation activity of integrin‐linked kinase (ILK) in the …