Integrins mediate cell adhesion and transmit mechanical and chemical signals to the cell
interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor …

Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

The selectins are transmembrane, Ca2+-dependent lectins that mediate leucocyte rolling on
vascular surfaces, the first adhesive step during inflammation and immune surveillance …

Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

Integrin αIIbβ3 is a highly abundant heterodimeric platelet receptor that can transmit
information bidirectionally across the plasma membrane, and plays a critical role in …

Focal adhesion (FA) assembly, mediated by integrin activation, responds to matrix stiffness;
however, the underlying mechanisms are unclear. Here, we showed that β1 integrin and …

Integrins are heterodimeric transmembrane adhesion receptors that couple the actin
cytoskeleton to the extracellular environment and bidirectionally relay signals across the cell …

Signaling pathways allow cells to detect and respond to a wide variety of chemical (eg Ca2+
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …

Recent studies at the nanometer scale have revealed that relatively uniform clusters of
adhesion proteins (50–100 nm) constitute the modular units of cell adhesion sites in both …

Integrins play an important role in cell adhesion by linking the cytoskeleton of cells to
components in the extracellular matrix. In this capacity, integrins cooperate with different cell …