Structural insights into SARS-CoV-2 proteins
The unprecedented scale of the ongoing COVID-19 pandemic has catalyzed an intense
effort of the global scientific community to unravel different aspects of the disease in a short …
effort of the global scientific community to unravel different aspects of the disease in a short …
Ubiquitination in the regulation of inflammatory cell death and cancer
The ubiquitin system is complex, multifaceted, and is crucial for the modulation of a vast
number of cellular processes. Ubiquitination is tightly regulated at different levels by a range …
number of cellular processes. Ubiquitination is tightly regulated at different levels by a range …
Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design
Viral papain-like cysteine protease (PLpro, NSP3) is essential for SARS-CoV-2 replication
and represents a promising target for the development of antiviral drugs. Here, we used a …
and represents a promising target for the development of antiviral drugs. Here, we used a …
Learning from the past: possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019‐nCoV
With the current trajectory of the 2019‐nCoV outbreak unknown, public health and medicinal
measures will both be needed to contain spreading of the virus and to optimize patient …
measures will both be needed to contain spreading of the virus and to optimize patient …
Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors
J Osipiuk, SA Azizi, S Dvorkin, M Endres… - Nature …, 2021 - nature.com
The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-
2) continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2 proteases …
2) continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2 proteases …
SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists
CK Yuen, JY Lam, WM Wong, LF Mak… - Emerging microbes & …, 2020 - Taylor & Francis
ABSTRACT The Coronavirus disease 2019 (COVID-19), which is caused by the novel SARS-
CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance …
CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance …
The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery
SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2
papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus …
papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus …
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
T Klemm, G Ebert, DJ Calleja, CC Allison… - The EMBO …, 2020 - embopress.org
The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …
Design of SARS-CoV-2 PLpro inhibitors for COVID-19 antiviral therapy leveraging binding cooperativity
Antiviral agents that complement vaccination are urgently needed to end the COVID-19
pandemic. The SARS-CoV-2 papain-like protease (PLpro), one of only two essential …
pandemic. The SARS-CoV-2 papain-like protease (PLpro), one of only two essential …
ISG15 in antiviral immunity and beyond
YC Perng, DJ Lenschow - Nature Reviews Microbiology, 2018 - nature.com
The host response to viral infection includes the induction of type I interferons and the
subsequent upregulation of hundreds of interferon-stimulated genes. Ubiquitin-like protein …
subsequent upregulation of hundreds of interferon-stimulated genes. Ubiquitin-like protein …