[HTML][HTML] Challenges and recent progress in oral drug delivery systems for biopharmaceuticals

B Homayun, X Lin, HJ Choi - Pharmaceutics, 2019 - mdpi.com
Routes of drug administration and the corresponding physicochemical characteristics of a
given route play significant roles in therapeutic efficacy and short term/long term biological …

Foundations of gastrointestinal-based drug delivery and future developments

JN Chu, G Traverso - Nature Reviews Gastroenterology & Hepatology, 2022 - nature.com
Gastrointestinal-based drug delivery is considered the preferred mode of drug
administration owing to its convenience for patients, which improves adherence. However …

[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Q Zhu, Z Chen, PK Paul, Y Lu, W Wu, J Qi - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

Non-invasive delivery strategies for biologics

AC Anselmo, Y Gokarn, S Mitragotri - Nature Reviews Drug Discovery, 2019 - nature.com
Biologics now constitute a significant element of available medical treatments. Owing to their
clinical and commercial success, biologics are a rapidly growing class and have become a …

Oral drug delivery platforms for biomedical applications

J Ouyang, Z Zhang, B Deng, J Liu, L Wang, H Liu… - Materials Today, 2023 - Elsevier
Oral administration is perhaps the most commonly used and acceptable route for drug
delivery to patients, mainly due to its non-invasiveness, simplicity, and versatility …

The current state of peptide drug discovery: back to the future?

A Henninot, JC Collins, JM Nuss - Journal of medicinal chemistry, 2018 - ACS Publications
Over the past decade, peptide drug discovery has experienced a revival of interest and
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …

Antimicrobial peptides–Advances in development of therapeutic applications

HX Luong, TT Thanh, TH Tran - Life sciences, 2020 - Elsevier
The severe infection is becoming a significant health problem which threaten the lives of
patients and the safety and economy of society. In the way of finding new strategy …

An ingestible self-orienting system for oral delivery of macromolecules

A Abramson, E Caffarel-Salvador, M Khang, D Dellal… - Science, 2019 - science.org
Biomacromolecules have transformed our capacity to effectively treat diseases; however,
their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limit …

Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors

A Abramson, MR Frederiksen, A Vegge, B Jensen… - Nature …, 2022 - nature.com
Oral administration provides a simple and non-invasive approach for drug delivery.
However, due to poor absorption and swift enzymatic degradation in the gastrointestinal …

Design principles of microneedles for drug delivery and sampling applications

Z Le, J Yu, YJ Quek, B Bai, X Li, Y Shou, B Myint, C Xu… - Materials Today, 2023 - Elsevier
Microneedles technology is a powerful platform to achieve efficient transdermal delivery of
bioactive molecules for local or systemic therapies attributing to their minimally invasive …