Global mapping of cancers: The Cancer Genome Atlas and beyond
Cancer genomes have been explored from the early 2000s through massive exome
sequencing efforts, leading to the publication of The Cancer Genome Atlas in 2013 …
sequencing efforts, leading to the publication of The Cancer Genome Atlas in 2013 …
The p53 family member p73 in the regulation of cell stress response
JM Rozenberg, S Zvereva, A Dalina, I Blatov, I Zubarev… - Biology direct, 2021 - Springer
During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …
homeostasis and resulting in subsequent hyperplasia. This process is paralleled by …
Liquid biopsies and cancer omics
The development of the sequencing technologies allowed the generation of huge amounts
of molecular data from a single cancer specimen, allowing the clinical oncology to enter the …
of molecular data from a single cancer specimen, allowing the clinical oncology to enter the …
Understanding p53 tumour suppressor network
The mutation of TP53 gene affects half of all human cancers, resulting in impairment of the
regulation of several cellular functions, including cell cycle progression and cell death in …
regulation of several cellular functions, including cell cycle progression and cell death in …
High throughput multi-omics approaches for clinical trial evaluation and drug discovery
High throughput single cell multi-omics platforms, such as mass cytometry (cytometry by time-
of-flight; CyTOF), high dimensional imaging (> 6 marker; Hyperion, MIBIscope, CODEX …
of-flight; CyTOF), high dimensional imaging (> 6 marker; Hyperion, MIBIscope, CODEX …
Low level of plasminogen increases risk for mortality in COVID-19 patients
D Della-Morte, F Pacifici, C Ricordi, R Massoud… - Cell death & …, 2021 - nature.com
The pathophysiology of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), and especially of its complications is still …
respiratory syndrome coronavirus 2 (SARS-CoV-2), and especially of its complications is still …
Glioblastoma pharmacotherapy: A multifaceted perspective of conventional and emerging treatments
AS Sevastre, A Costachi… - Experimental and …, 2021 - spandidos-publications.com
Due to its localisation, rapid onset, high relapse rate and resistance to most currently
available treatment methods, glioblastoma multiforme (GBM) is considered to be the …
available treatment methods, glioblastoma multiforme (GBM) is considered to be the …
The expression of ELOVL4, repressed by MYCN, defines neuroblastoma patients with good outcome
F Rugolo, NG Bazan, J Calandria, B Jun, G Raschellà… - Oncogene, 2021 - nature.com
Cancer cells exhibit dysregulation of critical genes including those involved in lipid
biosynthesis, with subsequent defects in metabolism. Here, we show that ELOngation of …
biosynthesis, with subsequent defects in metabolism. Here, we show that ELOngation of …
A Network Pharmacology Prediction and Molecular Docking-Based Strategy to Explore the Potential Pharmacological Mechanism of Astragalus membranaceus for …
Y Feng, P Zhu, D Wu, W Deng - International Journal of Molecular …, 2023 - mdpi.com
Glioma treatment in traditional Chinese medicine has a lengthy history. Astragalus
membranaceus, a traditional Chinese herb that is frequently utilized in therapeutic practice …
membranaceus, a traditional Chinese herb that is frequently utilized in therapeutic practice …
NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network
E Mammarella, C Zampieri, E Panatta, G Melino… - Biology Direct, 2021 - Springer
Most inactivating mutations in TP53 gene generates neomorphic forms of p53 proteins that
experimental evidence and clinical observations suggest to exert gain-of-function effects …
experimental evidence and clinical observations suggest to exert gain-of-function effects …