Mitochondria: a new therapeutic target in chronic kidney disease

S Granata, A Dalla Gassa, P Tomei, A Lupo… - Nutrition & …, 2015 - Springer
Cellular metabolic changes during chronic kidney disease (CKD) may induce higher
production of oxygen radicals that play a significant role in the progression of renal damage …

Oxidative stress in patients undergoing peritoneal dialysis: a current review of the literature

V Liakopoulos, S Roumeliotis, X Gorny… - Oxidative Medicine …, 2017 - Wiley Online Library
Peritoneal dialysis (PD) patients manifest excessive oxidative stress (OS) compared to the
general population and predialysis chronic kidney disease patients, mainly due to the …

Antioxidant supplementation in renal replacement therapy patients: is there evidence?

V Liakopoulos, S Roumeliotis, A Bozikas… - Oxidative medicine …, 2019 - Wiley Online Library
The disruption of balance between production of reactive oxygen species and antioxidant
systems in favor of the oxidants is termed oxidative stress (OS). To counteract the damaging …

Is oxidative stress an issue in peritoneal dialysis?

S Roumeliotis, T Eleftheriadis… - Seminars in …, 2019 - Wiley Online Library
During the last two decades, oxidative stress (OS) has emerged as a novel risk factor for a
variety of adverse events, including atherosclerosis and mortality in chronic kidney disease …

N-Acetylcysteine: more than preventing contrast-induced nephropathy in uremic patients—focus on the antioxidant and anti-inflammatory properties

D Cepaityte, K Leivaditis, G Varouktsi… - … Urology and Nephrology, 2023 - Springer
Oxidative stress (OS) has been recognized as a pathophysiologic mechanism underlying
the development and progression of chronic kidney disease (CKD). OS, which results from …

[HTML][HTML] N-acetylcysteine in kidney disease: Molecular Mechanisms, Pharmacokinetics, and Clinical Effectiveness

EY Hernández-Cruz, OE Aparicio-Trejo… - Kidney International …, 2024 - Elsevier
N-acetylcysteine (NAC) has shown beneficial effects in both acute and chronic kidney
disease in preclinical and clinical studies. Different dosage and administration forms of NAC …

Preserving residual renal function in dialysis patients: an update on evidence to assist clinical decision making

KD Kjaergaard, JD Jensen, CD Peters… - Nephrology Dialysis …, 2011 - academic.oup.com
It has been documented that preservation of residual renal function in dialysis patients
improves quality of life as well as survival. Clinical trials on strategies to preserve residual …

Preserving residual renal function in dialysis: what we know

N Patel, SL Hu - Seminars in Dialysis, 2015 - Wiley Online Library
Residual renal function confers a survival benefit among dialysis patients thought to be
related to greater volume removal and solute clearance. Whether the presence of residual …

Protective effect of N-acetylcysteine on progression to end-stage renal disease: necessity for prospective clinical trial

CY Liao, CH Chung, CC Wu, FH Lin, CH Tsao… - European Journal of …, 2017 - Elsevier
Background We aimed to evaluate the potential benefits of N-acetylcysteine (NAC) on the
risk of chronic kidney disease (CKD) progression to dialysis-requiring end-stage renal …

Effluent free radicals are associated with residual renal function and predict technique failure in peritoneal dialysis patients

H Morinaga, H Sugiyama, T Inoue… - Peritoneal Dialysis …, 2012 - journals.sagepub.com
Objective Residual renal function (RRF) is associated with low oxidative stress in peritoneal
dialysis (PD). In the present study, we investigated the relationship between the impact of …