Eukaryotic cell size control and its relation to biosynthesis and senescence

S Xie, M Swaffer, JM Skotheim - Annual review of cell and …, 2022 - annualreviews.org
The most fundamental feature of cellular form is size, which sets the scale of all cell
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …

Eukaryotic cell size regulation and its implications for cellular function and dysfunction

Y Chadha, A Khurana… - Physiological …, 2024 - journals.physiology.org
Depending on cell type, environmental inputs, and disease, the cells in the human body can
have widely different sizes. In recent years, it has become clear that cell size is a major …

RNA polymerase II dynamics and mRNA stability feedback scale mRNA amounts with cell size

MP Swaffer, GK Marinov, H Zheng, LF Valenzuela… - Cell, 2023 - cell.com
A fundamental feature of cellular growth is that total protein and RNA amounts increase with
cell size to keep concentrations approximately constant. A key component of this is that …

Decoupled transcript and protein concentrations ensure histone homeostasis in different nutrients

D Chatzitheodoridou, D Bureik, F Padovani… - The EMBO …, 2024 - embopress.org
To maintain protein homeostasis in changing nutrient environments, cells must precisely
control the amount of their proteins, despite the accompanying changes in cell growth and …

On the molecular mechanisms regulating animal cell size homeostasis

E Zatulovskiy, JM Skotheim - Trends in Genetics, 2020 - cell.com
Cell size is fundamental to cell physiology because it sets the scale of intracellular geometry,
organelles, and biosynthetic processes. In animal cells, size homeostasis is controlled …

High-resolution mass measurements of single budding yeast reveal linear growth segments

AP Cuny, K Tanuj Sapra, D Martinez-Martin… - Nature …, 2022 - nature.com
The regulation of cell growth has fundamental physiological, biotechnological and medical
implications. However, methods that can continuously monitor individual cells at sufficient …

Transcriptional and chromatin-based partitioning mechanisms uncouple protein scaling from cell size

MP Swaffer, J Kim, D Chandler-Brown, M Langhinrichs… - Molecular cell, 2021 - cell.com
Biosynthesis scales with cell size such that protein concentrations generally remain constant
as cells grow. As an exception, synthesis of the cell-cycle inhibitor Whi5" sub-scales" with …

What programs the size of animal cells?

S Liu, C Tan, M Tyers, A Zetterberg… - Frontiers in Cell and …, 2022 - frontiersin.org
The human body is programmed with definite quantities, magnitudes, and proportions. At the
microscopic level, such definite sizes manifest in individual cells-different cell types are …

Functional genomic and biochemical analysis reveals pleiotropic effect of Congo red on Aspergillus fumigatus

Z Liu, S Raj, N Van Rhijn, M Fraczek, JP Michel… - MBio, 2021 - Am Soc Microbiol
Inhibition of fungal growth by Congo red (CR) has been putatively associated with specific
binding to β-1, 3-glucans, which blocks cell wall polysaccharide synthesis. In this study, we …

The timing of Start is determined primarily by increased synthesis of the Cln3 activator rather than dilution of the Whi5 inhibitor

A Litsios, P Goswami, HM Terpstra… - Molecular biology of …, 2022 - Am Soc Cell Biol
RESULTS AND DISCUSSION There is little or no change in Whi5 concentration during G1 It
was originally proposed by Schmoller et al.(2015) that Whi5 concentration decreases during …