The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

Ethnopharmacological relevance Natural products play a critical role in drug development
and is emerging as a potential source of biologically active metabolites for therapeutic …

A series of 12 S‐substituted tetrahydrobenzothienopyrimidines were designed and
synthesized based on the donepezil scaffold. All the newly synthesized compounds were …

Targeting thioredoxin reductase (TXNRD) with low-weight molecules is emerging as a high-
efficacy anti-cancer strategy in chemotherapy. Sanguinarine has been reported to inhibit the …

Since multiple myeloma (MM) remains a cureless malignancy of plasma cells to date, it
becomes imperative to develop novel drugs and therapeutic targets for MM. We screened a …

Covering: 2019 to 2023 Isoquinoline alkaloids, an important class of N-based heterocyclic
compounds, have attracted considerable attention from researchers worldwide. To follow up …

Epithelial–mesenchymal transition (EMT) is a critical process for cancer progression, which
is crucial in inhibiting the immunity in tumors and further boosting tumor metastasis. The …

The increasing prevalence of particulate matter (PM) has raised significant concerns about
its adverse effects on human health. This study investigates the potential of fermented …

Neuronal injury and apoptosis are important causes of the occurrence and development of
many neurodegenerative diseases, such as cerebral ischemia, Alzheimer's disease, and …

Difficult or even non-healing diabetic foot ulcers (DFU) are a global medical challenge.
Although current treatments such as debridement, offloading, and infection control have …