Genetics of obesity: what we have learned over decades of research

C Bouchard - Obesity, 2021 - Wiley Online Library
There is a genetic component to human obesity that accounts for 40% to 50% of the
variability in body weight status but that is lower among normal weight individuals (about …

Recent progress in epigenetics of obesity

FY Wu, RX Yin - Diabetology & Metabolic Syndrome, 2022 - Springer
Nowadays, obesity is one of the largest public health problems worldwide. In the last few
decades, there has been a marked increase in the obesity epidemic and its related …

Genome-wide DNA methylation and gene expression analyses in monozygotic twins identify potential biomarkers of depression

W Wang, W Li, Y Wu, X Tian, H Duan, S Li… - Translational …, 2021 - nature.com
Depression is currently the leading cause of disability around the world. We conducted an
epigenome-wide association study (EWAS) in a sample of 58 depression score-discordant …

Examining the association between adiposity and DNA methylation: a systematic review and meta‐analysis

WL Do, J Gohar, LE McCullough, KI Galaviz… - Obesity …, 2021 - Wiley Online Library
Obesity is associated with widespread differential DNA methylation (DNAm) patterns, though
there have been limited overlap in the obesity‐associated cytosine–guanine nucleotide pair …

Ribosomal DNA copy number is associated with body mass in humans and other mammals

PP Law, LA Mikheeva, F Rodriguez-Algarra… - Nature …, 2024 - nature.com
Body mass results from a complex interplay between genetics and environment. Previous
studies of the genetic contribution to body mass have excluded repetitive regions due to the …

Genetics and Epigenetics in Obesity: What Do We Know so Far?

M Keller, SIA Svensson, K Rohde-Zimmermann… - Current Obesity …, 2023 - Springer
Abstract Purpose of Review Enormous progress has been made in understanding the
genetic architecture of obesity and the correlation of epigenetic marks with obesity and …

Epigenome-wide association study in Chinese monozygotic twins identifies DNA methylation loci associated with blood pressure

W Wang, J Yao, W Li, Y Wu, H Duan, C Xu, X Tian… - Clinical …, 2023 - Springer
Background Hypertension is a crucial risk factor for developing cardiovascular disease and
reducing life expectancy. We aimed to detect DNA methylation (DNAm) variants potentially …

DNA methylation and waist-to-hip ratio: an epigenome-wide association study in Chinese monozygotic twins

Y Wu, H Tian, W Wang, W Li, H Duan… - Journal of Endocrinological …, 2022 - Springer
Purpose Epigenetic signatures such as DNA methylation may be associated with specific
obesity traits. We performed an epigenome-wide association study (EWAS) by combining …

Genome-wide DNA methylation analysis of cognitive function in middle and old-aged Chinese monozygotic twins

W Wang, W Li, W Jiang, H Lin, Y Wu, Y Wen… - Journal of Psychiatric …, 2021 - Elsevier
Cognitive ability plays an important role in mental and physical well-beings in the
increasingly ageing populations. Here, based on a sample of 30 cognitive function …

Genome-wide DNA methylation analysis of pulmonary function in middle and old-aged Chinese monozygotic twins

T Wang, W Wang, W Li, H Duan, C Xu, X Tian… - Respiratory …, 2021 - Springer
Background Previous studies have determined the epigenetic association between DNA
methylation and pulmonary function among various ethnics, whereas this association is …