Podocytes maintain the glomerular filtration barrier, and the stability of this barrier depends
on their highly differentiated postmitotic phenotype, which also defines the particular …

Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from
adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin …

Podocytes are critical for maintaining permselectivity of the glomerular filtration barrier, and
podocyte injury is a major cause of proteinuria in various primary and secondary …

Impaired cellular cholesterol efflux is a key factor in the progression of renal, cardiovascular,
and autoimmune diseases. Here we describe a class of 5-arylnicotinamide compounds …

Background: Podocytes, functionally specialized and terminally differentiated glomerular
visceral epithelial cells, are critical for maintaining the structure and function of the …

Background To establish a model of chronic renal fibrosis following acute kidney injury (AKI)
in BALB/c mice and to observe the effect of AKI on podocyte injury and chronic fibrosis of the …

Advances in the understanding of lipid droplet biology have revealed essential roles for
these organelles in mediating proper cellular homeostasis and stress response. Lipid …

Focal segmental glomerulosclerosis (FSGS) represents a glomerular scar formation
downstream of various different mechanisms leading to podocytopathy and podocyte loss …

Acute crystalline nephropathy is closely related to tubulointerstitial injury, but few studies
have investigated glomerular changes in this condition. Thus, in the current study, we …

Nephropathy has become the most common reason for end-stage renal disease worldwide.
The progression of end-stage renal disease occurs caused by decreased glomerular …