Mitochondria and calcium in Alzheimer's disease: from cell signaling to neuronal cell death
M Calvo-Rodriguez, BJ Bacskai - Trends in neurosciences, 2021 - cell.com
Mitochondrial dysfunction has been implicated in the pathogenesis of almost all
neurological diseases, including Alzheimer's disease (AD). Historically, a primary focus in …
neurological diseases, including Alzheimer's disease (AD). Historically, a primary focus in …
[HTML][HTML] Genetics of Alzheimer's disease: where we are, and where we are going
C Bellenguez, B Grenier-Boley, JC Lambert - Current Opinion in …, 2020 - Elsevier
Highlights•More than 40 loci of interest have been associated with the risk of developing
AD.•Recent genetic data clearly implicate microglia as involved in the pathophysiological …
AD.•Recent genetic data clearly implicate microglia as involved in the pathophysiological …
New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
[PDF][PDF] Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
The impact of apolipoprotein E ε4 (APOE4), the strongest genetic risk factor for Alzheimer's
disease (AD), on human brain cellular function remains unclear. Here, we investigated the …
disease (AD), on human brain cellular function remains unclear. Here, we investigated the …
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease
Innate immunity is associated with Alzheimer's disease, but the influence of immune
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …
Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer's disease pathogenesis
Genome-wide association studies (GWAS) have identified many risk loci for Alzheimer's
disease (AD),, but how these loci confer AD risk is unclear. Here, we aimed to identify loci …
disease (AD),, but how these loci confer AD risk is unclear. Here, we aimed to identify loci …
[PDF][PDF] The major risk factors for Alzheimer's disease: age, sex, and genes modulate the microglia response to Aβ plaques
CS Frigerio, L Wolfs, N Fattorelli, N Thrupp, I Voytyuk… - Cell reports, 2019 - cell.com
Gene expression profiles of more than 10,000 individual microglial cells isolated from cortex
and hippocampus of male and female App NL-GF mice over time demonstrate that …
and hippocampus of male and female App NL-GF mice over time demonstrate that …
Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease
M Calvo-Rodriguez, SS Hou, AC Snyder… - Nature …, 2020 - nature.com
Mitochondria contribute to shape intraneuronal Ca2+ signals. Excessive Ca2+ taken up by
mitochondria could lead to cell death. Amyloid beta (Aβ) causes cytosolic Ca2+ overload …
mitochondria could lead to cell death. Amyloid beta (Aβ) causes cytosolic Ca2+ overload …
An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease
Protein aggregation is the hallmark of neurodegeneration, but the molecular mechanisms
underlying late-onset Alzheimer's disease (AD) are unclear. Here we integrated …
underlying late-onset Alzheimer's disease (AD) are unclear. Here we integrated …
Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes
Genome-wide association studies (GWAS) have identified more than 40 loci associated with
Alzheimer's disease (AD), but the causal variants, regulatory elements, genes and pathways …
Alzheimer's disease (AD), but the causal variants, regulatory elements, genes and pathways …