Molecular modeling approaches to address drug-metabolizing enzymes (DMEs) mediated chemoresistance: a review
Resistance against clinically approved anticancer drugs is the main roadblock in cancer
treatment. Drug metabolizing enzymes (DMEs) that are capable of metabolizing a variety of …
treatment. Drug metabolizing enzymes (DMEs) that are capable of metabolizing a variety of …
A triple-drug nanotherapy to target breast cancer cells, cancer stem cells, and tumor vasculature
S El-Sahli, K Hua, A Sulaiman, J Chambers, L Li… - Cell death & …, 2021 - nature.com
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer,
accounting for the majority of breast cancer-related death. Due to the lack of specific …
accounting for the majority of breast cancer-related death. Due to the lack of specific …
Oral self-emulsifying nanoemulsion systems for enhancing dissolution, bioavailability and anticancer effects of camptothecin
ST Galatage, R Trivedi, DA Bhagwat - Journal of Drug Delivery Science …, 2022 - Elsevier
This research aimed to prepare a camptothecin (CPT) loaded self nano emulsifying drug
delivery system (SNEDDS) that would improve the oral therapeutic efficacy of CPT. 3 2 full …
delivery system (SNEDDS) that would improve the oral therapeutic efficacy of CPT. 3 2 full …
Designing a multi-epitope subunit vaccine against VP1 major coat protein of JC polyomavirus
S Kanse, M Khandelwal, RK Pandey, M Khokhar… - Vaccines, 2023 - mdpi.com
The JC polyomavirus virus (JCPyV) affects more than 80% of the human population in their
early life stage. It mainly affects immunocompromised individuals where virus replication in …
early life stage. It mainly affects immunocompromised individuals where virus replication in …
Analyzing the Impact of the Substituent on the Quinazolinone Schiff Base and the Interaction of the Fe (III) and Cr (III) with Different Quinazolinone Schiff Base for …
A Pore, G Gaikwad, S Hegade, Y Jadhav… - Analytical Chemistry …, 2023 - Taylor & Francis
Schiff base and their Fe (III), Cr (III) complexes stood vetted for Antioxidant, Anti-inflammatory
activities and docking study. Mixed ligand complexes had strong antioxidant and anti …
activities and docking study. Mixed ligand complexes had strong antioxidant and anti …
Aminoglycoside antibiotic kanamycin functionalized tetraphenylethylene molecular probe for highly selective detection of bovine serum albumin protein
A novel tetraphenylethylene (TPE) functionalized aminoglycoside antibiotic kanamycin (TPE-
kana 1) has been successfully synthesized and characterized by means of modern …
kana 1) has been successfully synthesized and characterized by means of modern …
Evaluation of In Vitro Antiprotease Activity of Selected Traditional Medicinal Herbs in Dentistry and Its In Silico PASS Prediction
AA Assiry, SK Bhavikatti, FA Althobaiti… - BioMed Research …, 2022 - Wiley Online Library
Background. Dental/oral diseases are one of the significant public health problems globally.
Herbal medicines for managing oral diseases are considered an effective alternative to …
Herbal medicines for managing oral diseases are considered an effective alternative to …
Exploring the interaction of Peloruside-A with drug resistant αβII and αβIII tubulin isotypes in human ovarian carcinoma using a molecular modeling approach
BV Kumbhar, VV Bhandare - Journal of Biomolecular Structure and …, 2021 - Taylor & Francis
Microtubules (MTs) play an essential role in mitosis; hence they are identified as potential
targets to design novel anti-mitotic agents. MT's are composed of α/β-tubulin isotypes that …
targets to design novel anti-mitotic agents. MT's are composed of α/β-tubulin isotypes that …
Discerning computational, in vitro and in vivo investigations of self-assembling empagliflozin polymeric micelles in type-2 diabetes
P Wagh, S Savaliya, B Joshi, B Vyas… - Drug Delivery and …, 2024 - Springer
Background Empagliflozin (EMPA) is an SGLT2 inhibitor, a new class of anti-diabetic
medication, indicated for treating type-2 diabetes. Its low permeability, poor solubility and …
medication, indicated for treating type-2 diabetes. Its low permeability, poor solubility and …
[HTML][HTML] Three Prime Repair Exonuclease 1 preferentially degrades the integration-incompetent HIV-1 DNA through favorable kinetics, thermodynamic, structural and …
HIV-1 integration into the human genome is dependent on 3'-processing of the viral DNA.
Recently, we reported that the cellular Three Prime Repair Exonuclease 1 (TREX1) …
Recently, we reported that the cellular Three Prime Repair Exonuclease 1 (TREX1) …