Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament

T Liu, CAO LuYan, M Mladenov, AG Jegou, M Way… - Biophysical …, 2024 - cell.com
The actin cytoskeleton can form many different types of dynamic supramolecular arrays-from
linear bundles to branched actin filament networks which underlie its functional diversity and …

Contractile and expansive actin networks in Drosophila: Developmental cell biology controlled by network polarization and higher-order interactions

R Fernandez-Gonzalez, TJC Harris - Current Topics in Developmental …, 2023 - Elsevier
Actin networks are central to shaping and moving cells during animal development. Various
spatial cues activate conserved signal transduction pathways to polarize actin network …

Centrosome-organized plasma membrane infoldings linked to growth of a cortical actin domain

R Tam, TJC Harris - Journal of Cell Biology, 2024 - rupress.org
Regulated cell shape change requires the induction of cortical cytoskeletal domains. Often,
local changes to plasma membrane (PM) topography are involved. Centrosomes organize …

A Rab39-Klp98A-Rab35 endocytic recycling pathway is essential for rapid Golgi-dependent furrow ingression

H Miao, M Millage, KR Rollins… - Development, 2023 - journals.biologists.com
Ingression of the plasma membrane is an essential part of the cell topology-distorting
repertoire and a key element in animal cell cytokinesis. Many embryos have rapid cleavage …

[HTML][HTML] Sponge/DOCK-dependent regulation of F-actin networks directing cortical cap behaviors and syncytial furrow ingression

SM Henry, Y Xie, KR Rollins, JT Blankenship - Developmental Biology, 2022 - Elsevier
In the early syncytial Drosophila embryo, rapid changes in filamentous actin networks and
membrane trafficking pathways drive the formation and remodeling of cortical and furrow …

SCAR/WAVE complex recruitment to a supracellular actomyosin cable by myosin activators and a junctional Arf-GEF during Drosophila dorsal closure

EL Hunt, H Rai, TJC Harris - Molecular Biology of the Cell, 2022 - Am Soc Cell Biol
Expansive Arp2/3 actin networks and contractile actomyosin networks can be spatially and
temporally segregated within the cell, but the networks also interact closely at various sites …

Dysregulation of the endoplasmic reticulum blocks recruitment of centrosome-associated proteins resulting in mitotic failure

KR Rollins, JT Blankenship - Development, 2023 - journals.biologists.com
The endoplasmic reticulum (ER) undergoes a remarkable transition in morphology during
cell division to aid in the proper portioning of the ER. However, whether changes in ER …

Reshaping the Syncytial Drosophila Embryo with Cortical Actin Networks: Four Main Steps of Early Development

R Tam, TJC Harris - Syncytia: Origin, Structure, and Functions, 2023 - Springer
Drosophila development begins as a syncytium. The large size of the one-cell embryo
makes it ideal for studying the structure, regulation, and effects of the cortical actin …

Bitesize bundles F-actin and influences actin remodeling in syncytial Drosophila embryo development

AR Yeh, GJ Hoeprich, BL Goode, AC Martin - bioRxiv, 2023 - biorxiv.org
Actin networks undergo rearrangements that influence cell and tissue shape. Actin network
assembly and organization is regulated in space and time by a host of actin binding …

Emergence of a smooth interface between cytoskeleton materials explained by mathematical modeling

M Sharma - 2022 - search.proquest.com
Structures and machines require smoothening of raw materials. Self-organized smoothening
guides cell and tissue morphogenesis and is relevant to advanced manufacturing. Across …