The neuroprotective effects of experience on cognitive functions: evidence from animal studies on the neurobiological bases of brain reserve

F Gelfo, L Mandolesi, L Serra, G Sorrentino… - Neuroscience, 2018 - Elsevier
Brain plasticity is the ability of the nervous system to change structurally and functionally in
response to experience. By shaping brain structure and function, experience leads to the …

Environmental factors promoting neural plasticity: insights from animal and human studies

L Mandolesi, F Gelfo, L Serra, S Montuori… - Neural …, 2017 - Wiley Online Library
We do not all grow older in the same way. Some individuals have a cognitive decline earlier
and faster than others who are older in years but cerebrally younger. This is particularly easy …

Environmental enrichment effects on the brain-derived neurotrophic factor expression in healthy condition, Alzheimer's disease, and other neurodegenerative …

D Cutuli, E Landolfo, L Petrosini… - Journal of Alzheimer's …, 2022 - content.iospress.com
Brain-derived neurotrophic factor (BDNF), a protein belonging to the neurotrophin family, is
known to be heavily involved in synaptic plasticity processes that support brain …

Search strategy selection in the Morris water maze indicates allocentric map formation during learning that underpins spatial memory formation

J Rogers, L Churilov, AJ Hannan, T Renoir - Neurobiology of learning and …, 2017 - Elsevier
Using a Matlab classification algorithm, we demonstrate that a highly salient distal cue array
is required for significantly increased likelihoods of spatial search strategy selection during …

Neurobehavioral effects of restricted and unpredictable environmental enrichment in rats

M Rojas-Carvajal, A Sequeira-Cordero… - Frontiers in …, 2020 - frontiersin.org
To study how motivational factors modulate experience-dependent neurobehavioral
plasticity, we modify a protocol of environmental enrichment (EE) in rats. We assumed that …

Environmental enrichment reduces chronic psychosocial stress-induced anxiety and ethanol-related behaviors in mice

A Bahi - Progress in Neuro-Psychopharmacology and …, 2017 - Elsevier
Previous research from our laboratory has shown that exposure to chronic psychosocial
stress increased voluntary ethanol consumption and preference as well as acquisition of …

Long-term effects of enriched environment following neonatal hypoxia-ischemia on behavior, BDNF and synaptophysin levels in rat hippocampus: effect of combined …

M Griva, R Lagoudaki, O Touloumi, E Nousiopoulou… - Brain research, 2017 - Elsevier
Increasing evidence shows that exposure to an enriched environment (EE) is
neuroprotective in adult and neonatal animal models of brain ischemia. However, the …

Effect of physical and social components of enriched environment on astrocytes proliferation in rats after cerebral ischemia/reperfusion injury

X Chen, X Zhang, W Liao, Q Wan - Neurochemical research, 2017 - Springer
Abstract Treatment of enriched environment (EE) exerts neuroprotective effect in cerebral
ischemia/reperfusion (I/R) injury. However, how the component of EE contributes to the …

Beneficial effects and neurobiological aspects of environmental enrichment associated to major depressive disorder and autism spectrum disorder

LM Manosso, LDR Broseghini, JMB Campos… - Brain Research …, 2022 - Elsevier
A suitable enriched environment favors development but can also influence behavior and
neuronal circuits throughout development. Studies have shown that environmental …

An enriched environment delays the progression from mild cognitive impairment to Alzheimer's disease in senescence‑accelerated mouse prone 8 mice

JZ Li, XH Hao, HP Wu, M Li… - Experimental and …, 2021 - spandidos-publications.com
A previous study demonstrated that middle‑aged (5‑6 months of age) senescence‑
accelerated mouse prone 8 (SAMP8) mice can be used as animal models of mild cognitive …