Biology of poly (ADP-ribose) polymerases: the factotums of cell maintenance
P Bai - Molecular cell, 2015 - cell.com
The protein family of poly (ADP-ribose) polymerases (PARPs) or diphtheria toxin-type ADP-
ribose transferases (ARTDs) are multidomain proteins originally identified as DNA repair …
ribose transferases (ARTDs) are multidomain proteins originally identified as DNA repair …
[HTML][HTML] Role of hypoxia in cellular senescence
Senescent cells persist and continuously secrete proinflammatory and tissue-remodeling
molecules that poison surrounding cells, leading to various age-related diseases, including …
molecules that poison surrounding cells, leading to various age-related diseases, including …
Tanshinone IIA inhibits β-catenin/VEGF-mediated angiogenesis by targeting TGF-β1 in normoxic and HIF-1α in hypoxic microenvironments in human colorectal …
H Sui, J Zhao, L Zhou, H Wen, W Deng, C Li, Q Ji, X Liu… - Cancer letters, 2017 - Elsevier
In a previous study, we demonstrated that Tanshinone IIA effectively inhibits CRC
angiogenesis in vivo, but the underlying mechanisms were not elucidated. In this report, we …
angiogenesis in vivo, but the underlying mechanisms were not elucidated. In this report, we …
Transcriptional roles of PARP1 in cancer
MJ Schiewer, KE Knudsen - Molecular cancer research, 2014 - AACR
Abstract Poly (ADP-ribose) polymerase-1 (PARP1) is an abundant, ubiquitously expressed
NAD+-dependent nuclear enzyme that has prognostic value for a multitude of human …
NAD+-dependent nuclear enzyme that has prognostic value for a multitude of human …
The role of hypoxia‐inducible factor‐2 alpha in angiogenesis
Angiogenesis is a key enabling feature of mammalian embryonic development and tumor
progression, which provides oxygen and nutrients that are required for vessel growth and …
progression, which provides oxygen and nutrients that are required for vessel growth and …
A compendium of proteins that interact with HIF-1α
GL Semenza - Experimental cell research, 2017 - Elsevier
Abstract Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of
transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is …
transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is …
[HTML][HTML] Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions
JM Martí, A Garcia-Diaz, D Delgado-Bellido, F O'Valle… - Redox Biology, 2021 - Elsevier
Background The adaptation to hypoxia is mainly controlled by the HIF transcription factors.
Increased expression/activity of HIF-1α correlates with poor prognosis in cancer patients …
Increased expression/activity of HIF-1α correlates with poor prognosis in cancer patients …
Poly (ADP-ribose) polymerases as modulators of mitochondrial activity
Mitochondria are essential in cellular stress responses. Mitochondrial output to
environmental stress is a major factor in metabolic adaptation and is regulated by a complex …
environmental stress is a major factor in metabolic adaptation and is regulated by a complex …
The PARP enzyme family and the hallmarks of cancer part 1. cell intrinsic hallmarks
MA Demény, L Virág - Cancers, 2021 - mdpi.com
Simple Summary Poly (ADP-ribose) polymerase (PARP) proteins regulate DNA damage
correction, replication, and gene transcription. By controlling pivotal aspects of these …
correction, replication, and gene transcription. By controlling pivotal aspects of these …
[HTML][HTML] Brain adaptation to hypoxia and hyperoxia in mice
L Terraneo, R Paroni, P Bianciardi, T Giallongo… - Redox biology, 2017 - Elsevier
Aims Hyperoxic breathing might lead to redox imbalance and signaling changes that affect
cerebral function. Paradoxically, hypoxic breathing is also believed to cause oxidative …
cerebral function. Paradoxically, hypoxic breathing is also believed to cause oxidative …