Hematopoietic stem cells (HSCs) generated during embryonic development are able to
maintain hematopoiesis for the lifetime, producing all mature blood lineages. HSC …

Rare hematopoietic stem cells (HSCs) can self-renew, establish the entire blood system and
represent the basis of regenerative medicine applied to hematological disorders. Clinical …

Reactive oxygen species (ROS) represent a by-product of metabolism and their excess is
toxic for hematopoietic stem and progenitor cells (HSPCs). During embryogenesis, a small …

Efficient ex vivo expansion of hematopoietic stem cells with a concomitant preservation of
stemness and self‐renewal potential is still an unresolved ambition. Increased numbers of …

In mammals, embryonic hematopoiesis occurs in successive waves, culminating with the
emergence of hematopoietic stem cells (HSCs) in the aorta. HSCs first migrate to the fetal …

Early gene therapy studies held great promise for the cure of heritable diseases, but the
occurrence of various genotoxic events led to a pause in clinical trials and a more guarded …

Background Pim (p roviral i nsertion in m urine lymphoma) kinases are a small family of
constitutively active, highly conservative serine/threonine oncogenic kinases and have 3 …

The lack of copper has been associated with anemia, myelodysplastic syndromes and
leukemia as well as with a loss in complex IV activity and an enlarged mitochondrial …

Background Myelodysplastic syndromes (MDS) are a group of heterogeneous diseases with
variable clinical course. Predicting disease progression is difficult due to lack of specific …

Background: The ex vivo generation of human hematopoietic stem cells (HSCs) with long-
term repopulating capacity and multi-lineage differentiation potential represents the holy …