'Aging epigenetics' is an emerging field that promises exciting revelations in the near future.
Here we focus on the functional and biological significance of the epigenetic alterations that …

Covalent modifications of histones are central to the regulation of chromatin dynamics, and,
therefore, many biological processes involving chromatin, such as replication, repair …

Advances in laboratory sciences offer much in the challenge to unravel the complex etiology
of cancer and to therefore provide an evidence‐base for prevention. One area where …

The role of epigenetics in aging and age-related diseases is a key issue in molecular
physiology and medicine because certain epigenetic factors are thought to mediate, at least …

The eukaryotic DNA is wrapped around histone octamers, which consist of four different
histones, H2A, H2B, H3 and H4. The N-terminal tail of each histone is post-transcriptionally …

The temporal and spatial regulation of gene expression in mammalian development is
linked to the establishment of functional chromatin domains. Here, we report that tissue …

The development of organisms requires concerted changes in gene activity. The free radical
theory of development proposes that oxygen serves as a morphogen to educe development …

The risk of having cancer increases with age probably because progenitor cells from mature
organisms accumulate enough molecular lesions to evade the homeostatic control of their …

Despite extensive studies on mammalian neurogenesis, its post-transcriptional regulation
remains under-explored. Here we report that neural-specific inactivation of two murine post …

Alterations in RNA levels are frequently reported in brain of subjects diagnosed with autism,
schizophrenia, depression, and other psychiatric diseases, but it remains unclear whether …