Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors
Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) is an enzyme and a very omnipresent zinc
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
A critical review on recent trends on pharmacological applications of pyrazolone endowed derivatives
Pyrazolone is a well-known influential synthon for the synthesis of many molecules which
hold remarkable potential in the advancement of functional materials, coordination …
hold remarkable potential in the advancement of functional materials, coordination …
Recent advancements in the development of bioactive pyrazoline derivatives
Pyrazolines remain privileged heterocycles in drug discovery. 2-Pyrazoline scaffold has
been proven as a ubiquitous motif which is present in a number of pharmacologically …
been proven as a ubiquitous motif which is present in a number of pharmacologically …
Thiazolyl-pyrazoline derivatives: In vitro and in silico evaluation as potential acetylcholinesterase and carbonic anhydrase inhibitors
Alzheimer's disease (AD) is a complex, predominant, and progressive form of dementia. The
treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of …
treatment of AD alters depending on the cognitive and behavioral symptoms. The utility of …
Biological effects of bis-hydrazone compounds bearing isovanillin moiety on the aldose reductase
Abstract Aldose reductase (ALR2), one of the metabolically important enzymes, catalyzes
the formation of sorbitol from glucose in the polyol pathway. ALR2 inhibition is required to …
the formation of sorbitol from glucose in the polyol pathway. ALR2 inhibition is required to …
Docking studies and molecular dynamics simulation of triazole benzene sulfonamide derivatives with human carbonic anhydrase IX inhibition activity
P Gopinath, MK Kathiravan - RSC advances, 2021 - pubs.rsc.org
Carbonic anhydrase IX has been used as a hypoxia endogenous marker in a range of solid
tumors including renal cell, lung, bladder and tumors of the head and neck. α-CA IX isozyme …
tumors including renal cell, lung, bladder and tumors of the head and neck. α-CA IX isozyme …
Thioamides in medicinal chemistry and as small molecule therapeutic agents
G Huang, T Cierpicki, J Grembecka - European Journal of Medicinal …, 2024 - Elsevier
Thioamides, which are fascinating isosteres of amides, have garnered significant attention in
drug discovery and medicinal chemistry programs, spanning peptides and small molecule …
drug discovery and medicinal chemistry programs, spanning peptides and small molecule …
Synthesis, characterization, and biological evaluation of some novel Schiff bases as potential metabolic enzyme inhibitors
In this study, a series of novel Schiff base derivatives containing a pyrazolone ring (2a–e)
were designed, successfully synthesized for the first time, and characterized by elemental …
were designed, successfully synthesized for the first time, and characterized by elemental …
A novel class of phenylpyrazolone-sulphonamides rigid synthetic anticancer molecules selectively inhibit the isoform IX of carbonic anhydrases guided by molecular …
All the previously reported phenylpyrazoles as carbonic anhydrase inhibitors (CAIs) were
found to have small sizes and high levels of flexibility, and hence showed low selectivity …
found to have small sizes and high levels of flexibility, and hence showed low selectivity …
Computational target-based screening of anti-MRSA natural products reveals potential multitarget mechanisms of action through peptidoglycan synthesis proteins
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the leading causes of bacterial
infections in both healthcare and community settings. MRSA can acquire resistance to any …
infections in both healthcare and community settings. MRSA can acquire resistance to any …