Pyroptosis is a novel inflammatory form of regulated cell death (RCD), characterized by cell
swelling, membrane rupture, and pro-inflammatory effects. It is recognized as a potent …

Diabetic kidney disease (DKD) is not only one of the main complications of diabetes, but
also the leading cause of the end-stage renal disease (ESRD). The occurrence and …

SARS-CoV-2 is a type of beta-CoV that develops acute pneumonia, which is an
inflammatory condition. A cytokine storm has been recognized as one of the leading causes …

Fibrosis is often the end result of chronic inflammation. It is characterized by the excessive
deposition of extracellular matrix. This leads to structural alterations in the tissue, causing …

Abstract Gaseous ammonia (NH 3), as a main air pollutant in pig farms and surrounding
areas, directly affects animal and human health. The lung, as an important organ for gas …

Tranilast has an ameliorative effect on myocardial fibrosis (MF), but the specific mechanism
has not been studied. S100A11 is a key regulator of collagen expression in MF. In this …

Pulmonary fibrosis is the end-stage change of a large class of lung diseases characterized
by the proliferation of fibroblasts and the accumulation of a large amount of extracellular …

The liver injury leads to an inflammatory response, which causes the activation of hepatic
stellate cells (HSCs) that further secrete ECM proteins and play an important role in liver …

The tumor microenvironment (TME) plays a crucial role in cancer progression and treatment
response. It comprises a complex network of stromal cells, immune cells, extracellular …

Idiopathic pulmonary fibrosis (IPF) is a progressive terminal lung disease, and therapies aim
to block fibrosis. Fibroblast proliferation is controlled by C/EBP-β, microRNA cluster 17-92 …