Alzheimer's disease (AD) challenges our society with an annual estimated cost of $1.08
trillion in the United States alone by 2050. 1 AD is a progressive irreversible neurological …

Converging lines of evidence suggest that progressive accumulation of the amyloid β‐
protein (Aβ) plays a central role in the genesis of Alzheimer's disease, but it was long …

Aβ1–42 is a self-associating peptide whose neurotoxic derivatives are thought to play a role
in Alzheimer's pathogenesis. Neurotoxicity of amyloid β protein (Aβ) has been attributed to …

Amyloid plaques are a neuropathological hallmark of Alzheimer's disease (AD), but their
relationship to neurodegeneration and dementia remains controversial. In contrast, there is …

Alzheimer's disease (AD) is an age‐related, progressive degenerative disorder that is
characterized by synapse and neuron loss in the brain and the accumulation of protein …

Ordered protein aggregation in the brain is a hallmark of Alzheimer's disease and scrapie.
The disease-specific amyloid fibrils comprise primarily a single protein, amyloid β, in …

The amyloid peptides Aβ40 and Aβ42 of Alzheimer's disease are thought to contribute
differentially to the disease process. Although Aβ42 seems more pathogenic than Aβ40, the …

Structural studies of Alzheimer's amyloid fibrils have revealed information about the structure
at different levels. The amyloid-β peptide has been examined in various solvents and …

Extensive research causally links amyloid-β peptide (Aβ) to Alzheimer's disease, although
the pathologically relevant Aβ conformation remains unclear. Aβ spontaneously aggregates …

Amyloid-β precursor protein (APP) is a membrane-spanning protein with a large
extracellular domain and a much smaller intracellular domain. It is the source of the amyloid …