Cellular spheroids are aggregates of cells that are being explored to address fundamental
biological questions and as building blocks for engineered tissues. Spheroids possess …

Due to the vasculature defects and/or the avascular nature of cartilage, as well as the
complex gradients for bone-cartilage interface regeneration and the layered zonal …

Modular biofabrication strategies using microtissues or organoids as biological building
blocks have great potential for engineering replacement tissues and organs at scale. Here …

Damaged or diseased bone can be treated using autografts or a range of different bone
grafting biomaterials, however limitations with such approaches has motivated increased …

Endochondral ossification (EO) is an essential biological process than underpins how
human bones develop, grow, and heal in the event of a fracture. So much is unknown about …

The development of tissue engineering strategies for treatment of large bone defects has
become increasingly relevant, given the growing demand for bone substitutes. Native bone …

Since three-dimensional (3D) bioprinting has emerged, it has continuously to evolved as a
revolutionary technology in surgery, offering new paradigms for reconstructive and …

Patients diagnosed with osteosarcoma undergo extensive surgical intervention and
chemotherapy resulting in dismal prognosis and compromised quality of life owing to poor …

Human bone has a strong regenerative capacity that allows for restoration of its function and
structure after damage. For degenerative bone diseases or large defects, bone regeneration …

Background A significant hurdle for potential cell‐based therapies is the subsequent survival
and regenerative capacity of implanted cells. While many exciting developments have …