Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

Ischemic stroke is a leading cause of death worldwide. A key secondary cell death
mechanism mediating neurological damage following the initial episode of ischemic stroke …

Microglia play critical roles in tissue homeostasis and can also modulate neuronal function
and synaptic connectivity. In contrast to astrocytes and oligodendrocytes, which arise from …

Microglial cells constitute the resident macrophage population of the CNS. Recent in vivo
studies have shown that microglia carry out active tissue scanning, which challenges the …

Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A
1 receptors (A 1 Rs) and the less abundant, but widespread, facilitatory A 2A Rs. It is …

Resident microglia and hematogenous macrophages play crucial roles in the pathogenetic
cascade following cerebral ischemia but may functionally differ regarding neuroprotective …

Phagocytic cell NADPH oxidase (NOX) generates reactive oxygen species (ROS) as part of
innate immunity. Unfortunately, ischemia can also induce this pathway and inflict damage on …

Stroke, a cerebrovascular injury, is the leading cause of disability and third leading cause of
death in the world. Recent reports indicate that inhibiting the inflammatory response to …

Microglial cells derive from fetal macrophages which immigrate into and disseminate
throughout the central nervous system (CNS) in early embryogenesis. After settling in the …

Microglial cells in culture and in situ express a defined pattern of K+ channels, which is
distinct from that of other glial cells and neurons. This pattern undergoes defined changes …