The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Background Multimorbidity and frailty are complex syndromes characteristics of aging. We
reviewed the literature and provided pooled estimations of any evidence regarding (a) the …

The aging process is driven by interrelated mechanisms that lead to the emergence of
characteristic phenotypes that include changes in body composition, energy production and …

Background Multimorbidity–having two or more coexisting chronic conditions–is highly
prevalent, costly, and disabling to older adults. Questions remain regarding chronic …

Multimorbidity—the co-occurrence of multiple diseases—is associated to poor prognosis,
but the scarce knowledge of its development over time hampers the effectiveness of clinical …

Background The aim of this study was to describe barriers and facilitators for shared
decision making (SDM) as experienced by older patients with multiple chronic conditions …

This systematic review aimed to synthesise multimorbidity profiling literature to identify
replicable and clinically meaningful groupings of multimorbidity. We searched six electronic …

The process of aging is associated with the appearance of low-grade subclinical
inflammation, termed inflammaging, that can accelerate age-related diseases. In Western …

Untangling the interdependency of infections, immunity and frailty may help to clarify their
roles in the maintenance of health in aging individuals, and the recent COVID-19 pandemic …

Multimorbidity and depression are complex multifactorial conditions with major implications
for older individuals, their families, and healthcare providers. In this scoping review, we …