Basement membranes provide structural support to epithelium, endothelium, muscles, fat
cells, Schwann cells, and axons. Basement membranes are multifunctional: they modulate …

Fibrosis, stiffening and scarring of an organ/tissue due to genetic abnormalities,
environmental factors, infection, and/or injury, is responsible for> 40% of all deaths in the …

Chronic liver damage leads to pathological accumulation of ECM proteins (liver fibrosis).
Comprehensive characterization of the human ECM molecular composition is essential for …

Tissue fibrosis remains a serious health condition with high morbidity and mortality rates.
There is a critical need to engineer model systems that better recapitulate the spatial and …

While the cellular mechanisms of liver regeneration have been thoroughly studied, the role
of extracellular matrix (ECM) in liver regeneration is still poorly understood. We utilized a …

Hepatic fibrosis is a foreshadowing of future adverse events like liver cirrhosis, liver failure,
and cancer. Hepatic stellate cell activation is the main event of liver fibrosis, which results in …

Fibrillar proteins are principal components of extracellular matrix (ECM) that confer
mechanical properties to tissues. Fibrosis can result from wound repair in nearly every tissue …

Liver sinusoidal endothelial cells (LSECs) undergo capillarization, or loss of fenestrae, and
produce basement membrane during liver fibrotic progression. DLL4, a ligand of the Notch …

Liver fibrosis biomarker, Type IV collagen, may function as hepatocarcinogenesis niche.
However, among the six isoforms, the isoforms providing tumor microenvironment and their …

The etiology of exaggerated fibrous capsule formation around silicone mammary implants
(SMI) is multifactorial but primarily induced by immune mechanisms towards the foreign …