Previous studies have shown that tumors under a hypoxic environment can induce an
important hypoxia-responsive element, hypoxia-induced factor-1α (HIF-1α), which can …

Skeletal muscle (SM) pain and fatigue are common in Fabry disease (FD). Here, we
undertook the investigation of the energetic mechanisms related to FD-SM phenotype. A …

Hepatocellular carcinoma (HCC) is one of the most common digestive malignancies. HCC It
ranges as the fifth most common cause of cancer mortality worldwide. While The prognosis …

Hypoxia-inducible factor (HIF)-1α represents an oxygen-sensitive subunit of HIF
transcriptional factor, which is usually degraded in normoxia and stabilized in hypoxia to …

BMD is characterized by a marked heterogeneity of gene mutations resulting in many
abnormal dystrophin proteins with different expression and residual functions. The smaller …

Background Duchenne muscular dystrophy (DMD) is an X-linked lethal genetic disorder for
which there is no effective treatment. Previous studies have shown that stem cell …

Myocardial infarction (MI) may cause irreversible damage or destroy to part of the heart
muscle, affecting the heart's ability and power to pump blood as efficiently as before, often …

Muscle fibers express particular isoforms of contractile proteins, depending on the fiber's
function and the organism's developmental stage. In the adult, after a muscle injury, newly …

Mechanical ventilation (MV) is essential for patients with sepsis-related respiratory failure
but can cause ventilator-induced diaphragm dysfunction (VIDD), which involves …

Background Hypoxia is known to modify skeletal muscle biological functions and muscle
regeneration. However, the mechanisms underlying the effects of hypoxia on human …