Genome-wide association studies (GWAS) have identified the PICALM (Phosphatidylinositol
binding clathrin-assembly protein) gene as the most significant genetic susceptibility locus …

Central nervous system (CNS) disorders and diseases are expected to rise sharply in the
coming years, partly because of the world's aging population. Medicines for the treatment of …

Aging is the main risk factor for the appearance of age‐related neurodegenerative diseases,
including Alzheimer's disease (AD). AD is the most common form of dementia, characterized …

This review provides a comprehensive examination of the role of clathrin-mediated
endocytosis (CME) in Alzheimer's disease (AD) pathogenesis, emphasizing its impact …

Neurodegenerative diseases encompass a wide range of debilitating and incurable brain
disorders characterized by the progressive deterioration of the nervous system's structure …

Alzheimer's disease (AD) is the most common form of dementia and is characterized by the
accumulation of amyloid-beta (Aβ) plaques and neurofibrillary Tau tangles in the brain. We …

Current amyloid beta-targeting approaches for Alzheimer's disease (AD) therapeutics only
slow cognitive decline for small numbers of patients. This limited efficacy exists because AD …

Hereditary spastic paraplegia (HSP) comprises a large group of neurogenetic disorders
characterized by progressive lower extremity spasticity. Neurological evaluation and genetic …

Down syndrome (DS) is the most common form of inherited intellectual disability caused by
trisomy of chromosome 21, presenting with intellectual impairment, craniofacial …

Parkinson's disease (PD), the fastest-growing neurological disorder globally, has a complex
etiology. A previous study by our group identified the p. G849D variant in neurexin 2 …