The brain's choroid plexus (CP), which operates as an anatomical and functional
'checkpoint', regulates the communication between brain and periphery and contributes to …

Neural stem cells (NSCs) persist in the adult mammalian brain and are able to give rise to
new neurons and glia throughout life. The largest stem cell niche in the adult mouse brain is …

The choroid plexus (ChP) is a vital brain barrier and source of cerebrospinal fluid (CSF).
Here, we use longitudinal two-photon imaging in awake mice and single-cell transcriptomics …

Mature multiciliated ependymal cells line the cerebral ventricles where they form a partial
barrier between the cerebrospinal fluid (CSF) and brain parenchyma and regulate local CSF …

Hypertension is extremely common, affecting approximately 1 in every 2 adults globally.
Chronic hypertension is the leading modifiable risk factor for cardiovascular disease and …

The brain is a complex organ, fundamentally changing across the day to perform basic
functions like sleep, thought, and regulating whole-body physiology. This requires a …

Transthyretin is a transport protein whose misfolding has been implicated in the
development of cardiac amyloidosis. Here, we examine the clinical correlates of …

Thyroid hormones (TH) are required for brain development and function. Cerebrospinal fluid
(CSF), which bathes the brain and spinal cord, contains TH as free hormones or as bound to …

The cerebrospinal fluid (CSF) provides mechanical protection for the brain and serves as a
brain dispersion route for nutrients, hormones, and metabolic waste. The CSF secretion rate …

There has been a significant increase in the prevalence of central nervous system (CNS)
disorders, resulting in a considerable decrease in the overall well-being for affected …