A Bansal, S Kaushik, S Kukreti - Frontiers in genetics, 2022 - frontiersin.org
A complete understanding of DNA double-helical structure discovered by James Watson and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven …
A Jain, G Wang, KM Vasquez - Biochimie, 2008 - Elsevier
DNA structure is a critical element in determining its function. The DNA molecule is capable of adopting a variety of non-canonical structures, including three-stranded (ie triplex) …
Double-stranded DNA is able to form triple-helical structures by accommodating a third nucleotide strand in its major groove. This sequence-specific process offers a potent …
RD Wells - Trends in biochemical sciences, 2007 - cell.com
Recent discoveries have revealed that simple repeating DNA sequences, which are known to adopt non-B DNA conformations (such as triplexes, cruciforms, slipped structures, left …
Repetitive genomic sequences can adopt a number of alternative DNA structures that differ from the canonical B-form duplex (ie non-B DNA). These non-B DNA-forming sequences …
RC Duardo, F Guerra, S Pepe, G Capranico - Biochimie, 2023 - Elsevier
Non-canonical secondary structures (NCSs) are alternative nucleic acid structures that differ from the canonical B-DNA conformation. NCSs often occur in repetitive DNA sequences and …
Genetic alterations in DNA can lead to cancer when it is present in proto-oncogenes, tumor suppressor genes, DNA repair genes etc. Examples of such alterations include deletions …
L Poggi, GF Richard - Microbiology and Molecular Biology …, 2021 - Am Soc Microbiol
Duplex DNA naturally folds into a right-handed double helix in physiological conditions. Some sequences of unusual base composition may nevertheless form alternative structures …
G Wang, KM Vasquez - Mutation Research/Fundamental and Molecular …, 2006 - Elsevier
Repetitive DNA sequences are abundant in eukaryotic genomes, and many of these sequences have the potential to adopt non-B DNA conformations. Genes harboring non-B …