Non-B DNA structure-induced genetic instability and evolution

J Zhao, A Bacolla, G Wang, KM Vasquez - Cellular and molecular life …, 2010 - Springer
Repetitive DNA motifs are abundant in the genomes of various species and have the
capacity to adopt non-canonical (ie, non-B) DNA structures. Several non-B DNA structures …

Non-canonical DNA structures: Diversity and disease association

A Bansal, S Kaushik, S Kukreti - Frontiers in genetics, 2022 - frontiersin.org
A complete understanding of DNA double-helical structure discovered by James Watson
and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven …

DNA triple helices: biological consequences and therapeutic potential

A Jain, G Wang, KM Vasquez - Biochimie, 2008 - Elsevier
DNA structure is a critical element in determining its function. The DNA molecule is capable
of adopting a variety of non-canonical structures, including three-stranded (ie triplex) …

Triplexator: detecting nucleic acid triple helices in genomic and transcriptomic data

FA Buske, DC Bauer, JS Mattick, TL Bailey - Genome research, 2012 - genome.cshlp.org
Double-stranded DNA is able to form triple-helical structures by accommodating a third
nucleotide strand in its major groove. This sequence-specific process offers a potent …

Non-B DNA conformations, mutagenesis and disease

RD Wells - Trends in biochemical sciences, 2007 - cell.com
Recent discoveries have revealed that simple repeating DNA sequences, which are known
to adopt non-B DNA conformations (such as triplexes, cruciforms, slipped structures, left …

Impact of alternative DNA structures on DNA damage, DNA repair, and genetic instability

G Wang, KM Vasquez - DNA repair, 2014 - Elsevier
Repetitive genomic sequences can adopt a number of alternative DNA structures that differ
from the canonical B-form duplex (ie non-B DNA). These non-B DNA-forming sequences …

[HTML][HTML] Non-B DNA structures as a booster of genome instability

RC Duardo, F Guerra, S Pepe, G Capranico - Biochimie, 2023 - Elsevier
Non-canonical secondary structures (NCSs) are alternative nucleic acid structures that differ
from the canonical B-DNA conformation. NCSs often occur in repetitive DNA sequences and …

Chromosomal translocations in cancer

M Nambiar, V Kari, SC Raghavan - … et Biophysica Acta (BBA)-Reviews on …, 2008 - Elsevier
Genetic alterations in DNA can lead to cancer when it is present in proto-oncogenes, tumor
suppressor genes, DNA repair genes etc. Examples of such alterations include deletions …

Alternative DNA Structures In Vivo: Molecular Evidence and Remaining Questions

L Poggi, GF Richard - Microbiology and Molecular Biology …, 2021 - Am Soc Microbiol
Duplex DNA naturally folds into a right-handed double helix in physiological conditions.
Some sequences of unusual base composition may nevertheless form alternative structures …

Non-B DNA structure-induced genetic instability

G Wang, KM Vasquez - Mutation Research/Fundamental and Molecular …, 2006 - Elsevier
Repetitive DNA sequences are abundant in eukaryotic genomes, and many of these
sequences have the potential to adopt non-B DNA conformations. Genes harboring non-B …